Piperacillin/Tazobactam

General

  • Type: Anti-Pseudomonal Penicillin
  • Dosage Forms:
  • Common Trade Names: Zosyn

Adult Dosing

General

  • 3.375 g IV q6 hours
  • Alt: 4.5 g q6-8 hours
  • Max: 18 g/day

Diverticulitis

  • 3.375 g IV q6 hours x 7-10 days

Pneumonia

  • CAP
    • 3.375 g IV q6 hours x 7-10 days
    • Only for P. aeruginosa caused or from aspiration[1]
  • Nosocomial
    • 4.5 g IV q6 hours x 7-14 days
    • + aminoglycoside or antipseudomonal fluoroquinolone

Pediatric Dosing[2]

A Piperacillin/Taxobactam 3.375g vial contains 3g piperacillin and 0.375g tazobactam (8:1 ratio)

General

  • <2 months
    • 100 mg piperacillin/kg/dose IV q6 hours
  • 2-9 months
    • 80 mg piperacillin/kg/dose IV q8 hours
  • >9 months
    • 100 mg piperacillin/kg/dose q8 hours
  • Max: 16 g/day

Appendicitis and/or Peritonitis

  • 2-9 months
    • 80 mg piperacillin/kg/dose IV q8 hours
  • >9 months
    • ≤40 kg: 100 mg piperacillin/kg/dose IV q8 hours
    • >40 kg: 3.375g (3000 mg piperacillin) IV q6 hours
  • Max: 16 g/day

Cystic Fibrosis, Pseudomonal Infection

  • 240-400 mg piperacillin/kg/day IV divided q8 hours;
    • Consider higher dose: 450-600 mg/kg/day IV divided q4-6 hours[3]

Special Populations

  • Pregnancy:
  • Lactation:
  • Renal Dosing
    • Adult
    • Pediatric
  • Hepatic Dosing
    • Adult
    • Pediatric

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Source

  1. Mandell, 2007
  2. Red Book, 2012
  3. Zobell JT, Waters CD, Young DC, et al, "Optimization of Anti-Pseudomonal Antibiotics for Cystic Fibrosis Pulmonary Exacerbations: II. Cephalosporins and Penicillins," Pediatr Pulmonol, 2013, 48(2):107-22. PubMed 22949297