Praziquantel: Difference between revisions
Neil.m.young (talk | contribs) (Text replacement - "rxn" to "reaction") |
ClaireLewis (talk | contribs) No edit summary |
||
(7 intermediate revisions by 3 users not shown) | |||
Line 1: | Line 1: | ||
==Administration== | ==Administration== | ||
*Type: | *Type: [[Antiparasitic]], anthelmintic | ||
*Dosage Forms: 600 | *Dosage Forms: 600 | ||
*Routes of Administration: Oral | *Routes of Administration: Oral | ||
Line 6: | Line 6: | ||
==Adult Dosing== | ==Adult Dosing== | ||
*Schistosomiasis: | *Schistosomiasis: 20mg/kg PO tid x1 day | ||
**Separate doses by 4-6h | **Separate doses by 4-6h | ||
**Give | **Give with food | ||
**Do not crush/chew | **Do not crush/chew | ||
*Liver flukes: | *Liver flukes: 25mg/kg PO tid x1 day | ||
**Separate doses by 4-6h | **Separate doses by 4-6h | ||
*Cysticercosis: | *Cysticercosis: 50mg/kg/day PO divided q8h x14 days | ||
**Off label use | **Off label use | ||
*Tapeworms: 5- | *Tapeworms: 5-25mg/kg PO x1 | ||
**Off label use | **Off label use | ||
==Pediatric Dosing== | ==Pediatric Dosing== | ||
===Only for children> 4 y/o === | ===Only for children> 4 y/o=== | ||
*Schistosomiasis: | *Schistosomiasis: 20mg/kg PO bid-tid x1 day | ||
*Liver flukes: | *Liver flukes: 25mg/kg PO tid x1-2 days | ||
*Cysticercosis: | *Cysticercosis: 50mg/kg/day PO divided q8h x14 days | ||
**Off label use | **Off label use | ||
*Tape worms: 5- | *Tape worms: 5-25mg/kg PO x1 | ||
**Off label use | **Off label use | ||
Line 46: | Line 46: | ||
*ocular cysticercosis | *ocular cysticercosis | ||
*CNS lesions | *CNS lesions | ||
*seizure | *seizure history | ||
==Adverse Reactions== | ==Adverse Reactions== | ||
Line 63: | Line 63: | ||
*headache | *headache | ||
*dizziness | *dizziness | ||
*abdominal pain/ | *abdominal pain/nausea and vomiting | ||
==Pharmacology== | ==Pharmacology== | ||
Line 76: | Line 76: | ||
==See Also== | ==See Also== | ||
*[[Schistosomiasis]] | |||
==References== | ==References== | ||
<Epocrates, UpToDate> | <Epocrates, UpToDate> | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] [[Category:ID]] |
Latest revision as of 21:51, 23 September 2019
Administration
- Type: Antiparasitic, anthelmintic
- Dosage Forms: 600
- Routes of Administration: Oral
- Common Trade Names: Biltricide
Adult Dosing
- Schistosomiasis: 20mg/kg PO tid x1 day
- Separate doses by 4-6h
- Give with food
- Do not crush/chew
- Liver flukes: 25mg/kg PO tid x1 day
- Separate doses by 4-6h
- Cysticercosis: 50mg/kg/day PO divided q8h x14 days
- Off label use
- Tapeworms: 5-25mg/kg PO x1
- Off label use
Pediatric Dosing
Only for children> 4 y/o
- Schistosomiasis: 20mg/kg PO bid-tid x1 day
- Liver flukes: 25mg/kg PO tid x1-2 days
- Cysticercosis: 50mg/kg/day PO divided q8h x14 days
- Off label use
- Tape worms: 5-25mg/kg PO x1
- Off label use
Special Populations
- Pregnancy Risk Factor B
Renal Dosing
- No renal dosing defined
Hepatic Dosing
- Caution advised with Child-Pugh Class B or C
Contraindications
- Allergy to class/drug
- ocular schistosomiasis
- ocular cysticercosis
- CNS lesions
- seizure history
Adverse Reactions
Serious
- Generalized hypersensitivity reaction
- polyserositis
- arrhythmias
- bradycardia
- ventricular fibrillation
- AV block
- diarrhea, bloody
- seizures
- Jarisch-Herxheimer reaction
Common
- malaise
- headache
- dizziness
- abdominal pain/nausea and vomiting
Pharmacology
- Half-life: 1-1.5hr
- Metabolism: CYP450
- Excretion: Urine
Mechanism of Action
- Increases cell membrane permeability
Comments
See Also
References
<Epocrates, UpToDate>