Difference between revisions of "Praziquantel"

(See Also)
(Text replacement - "0 mg" to "0mg")
Line 6: Line 6:
  
 
==Adult Dosing==
 
==Adult Dosing==
*Schistosomiasis: 20 mg/kg PO tid x1 day
+
*Schistosomiasis: 20mg/kg PO tid x1 day
 
**Separate doses by 4-6h
 
**Separate doses by 4-6h
 
**Give with food
 
**Give with food
Line 14: Line 14:
 
**Separate doses by 4-6h
 
**Separate doses by 4-6h
  
*Cysticercosis: 50 mg/kg/day PO divided q8h x14 days
+
*Cysticercosis: 50mg/kg/day PO divided q8h x14 days
 
**Off label use
 
**Off label use
  
Line 22: Line 22:
 
==Pediatric Dosing==
 
==Pediatric Dosing==
 
===Only for children> 4 y/o===
 
===Only for children> 4 y/o===
*Schistosomiasis: 20 mg/kg PO bid-tid x1 day
+
*Schistosomiasis: 20mg/kg PO bid-tid x1 day
  
 
*Liver flukes: 25 mg/kg PO tid x1-2 days
 
*Liver flukes: 25 mg/kg PO tid x1-2 days
  
*Cysticercosis: 50 mg/kg/day PO divided q8h x14 days
+
*Cysticercosis: 50mg/kg/day PO divided q8h x14 days
 
**Off label use
 
**Off label use
  

Revision as of 08:58, 20 July 2016

Administration

  • Type: Anthelmintic
  • Dosage Forms: 600
  • Routes of Administration: Oral
  • Common Trade Names: Biltricide

Adult Dosing

  • Schistosomiasis: 20mg/kg PO tid x1 day
    • Separate doses by 4-6h
    • Give with food
    • Do not crush/chew
  • Liver flukes: 25 mg/kg PO tid x1 day
    • Separate doses by 4-6h
  • Cysticercosis: 50mg/kg/day PO divided q8h x14 days
    • Off label use
  • Tapeworms: 5-25 mg/kg PO x1
    • Off label use

Pediatric Dosing

Only for children> 4 y/o

  • Schistosomiasis: 20mg/kg PO bid-tid x1 day
  • Liver flukes: 25 mg/kg PO tid x1-2 days
  • Cysticercosis: 50mg/kg/day PO divided q8h x14 days
    • Off label use
  • Tape worms: 5-25 mg/kg PO x1
    • Off label use

Special Populations

  • Pregnancy Risk Factor B

Renal Dosing

  • No renal dosing defined

Hepatic Dosing

  • Caution advised with Child-Pugh Class B or C

Contraindications

  • Allergy to class/drug
  • ocular schistosomiasis
  • ocular cysticercosis
  • CNS lesions
  • seizure history

Adverse Reactions

Serious

  • Generalized hypersensitivity reaction
  • polyserositis
  • arrhythmias
  • bradycardia
  • ventricular fibrillation
  • AV block
  • diarrhea, bloody
  • seizures
  • Jarisch-Herxheimer reaction

Common

  • malaise
  • headache
  • dizziness
  • abdominal pain/nausea and vomiting

Pharmacology

  • Half-life: 1-1.5hr
  • Metabolism: CYP450
  • Excretion: Urine

Mechanism of Action

  • Increases cell membrane permeability

Comments

See Also

References

<Epocrates, UpToDate>