Difference between revisions of "Proteinuria"

(Created page with "==Background== *Normal protein excretion 150mg/24 hours or 10mg/100mL *>3.5g/24h considered nephrotic range *Dipstick: more sensitive to albumin, less sensitive to Bence-Jones...")
 
 
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==Causes/Differential Diagnosis==
 
==Causes/Differential Diagnosis==
 
===Functional===
 
===Functional===
*Benign: fever/acute illness, cold exposure, orthostatic proteinuria, strenuous exercise, [[hypertension]]
+
*Benign: [[fever]]/acute illness, cold exposure, orthostatic proteinuria, strenuous exercise, [[hypertension]]
 
*[[CHF]], [[shock]]
 
*[[CHF]], [[shock]]
*[[Preeclampsia]]/eclampsia
+
*[[Preeclampsia]]/[[eclampsia]]/[[HELLP]], [[acute fatty liver of pregnancy
 
===Renal===
 
===Renal===
 
*Tubular dysfunction
 
*Tubular dysfunction
*Glomerular disease (e.g. [[glomerulonephritis]], diabetes, HIV, SLE, amyloid, IgA or membranous nephropathy)
+
*Glomerular disease (e.g. [[glomerulonephritis]], [[diabetes]], [[HIV]], [[SLE]], [[amyloidosis]], [[IgA nephropathy]] or membranous nephropathy)
 
*[[Nephrotic syndrome]]
 
*[[Nephrotic syndrome]]
 
*[[Pyelonephritis]]
 
*[[Pyelonephritis]]
 
*[[Malignant hypertension]]
 
*[[Malignant hypertension]]
 +
*[[Alport syndrome]]
 
===Drugs===
 
===Drugs===
*[[Aminoglycosides]], [[penicillin]s, [[amphotericin]]
+
*[[Aminoglycosides]], [[penicillin]s, [[amphotericin]], [[penicillamine]], [[deferasirox]]
 
*[[NSAIDs]], gold
 
*[[NSAIDs]], gold
 +
*[[Chloral hydrate toxicity]]
 +
*[[Lead toxicity]]
 
===Protein overload===
 
===Protein overload===
 
''Note: bence-jones globulins NOT detected on dipstick''
 
''Note: bence-jones globulins NOT detected on dipstick''
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===Other===
 
===Other===
 
*[[Gout]]
 
*[[Gout]]
*[[Hypokalemia]], Cushing's syndrome
+
*[[Hypokalemia]], [[Cushing's syndrome]]
 
*[[Electrocution]]
 
*[[Electrocution]]
*Polycystic kidney disease
+
*[[Polycystic kidney disease]]
 +
*[[Hepatorenal syndrome]]
 +
*[[Leptospirosis]]
 +
*[[Polyarteritis nodosa]]
 +
*[[Serum sickness]]
 +
*[[Scleroderma]]
 
===False Positives===
 
===False Positives===
*Menses or other vaginal bleeding
+
*Menses or other [[vaginal bleeding]]
 
*Highly concentrated urine
 
*Highly concentrated urine
 
*Alkaline urine
 
*Alkaline urine
*Acetazolamide, cephalosporins, bicarb
+
*[[Acetazolamide]], [[cephalosporins]], [[bicarbonate]]
  
 
==See Also==
 
==See Also==
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[[Category:Renal]]
 
[[Category:Renal]]
 +
[[Category:Symptoms]]

Latest revision as of 18:14, 16 October 2019

Background

  • Normal protein excretion 150mg/24 hours or 10mg/100mL
  • >3.5g/24h considered nephrotic range
  • Dipstick: more sensitive to albumin, less sensitive to Bence-Jones protein and globulins
    • "Trace" protein ≈ 10mg/100mL (i.e. upper limit of normal)

Causes/Differential Diagnosis

Functional

Renal

Drugs

Protein overload

Note: bence-jones globulins NOT detected on dipstick

Other

False Positives

See Also