Proteinuria

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Background

  • Normal protein excretion 150mg/24 hours or 10mg/100mL
  • >3.5g/24h considered nephrotic range
  • Dipstick: more sensitive to albumin, less sensitive to Bence-Jones protein and globulins
    • "Trace" protein ≈ 10mg/100mL (i.e. upper limit of normal)

Causes/Differential Diagnosis

Functional

Renal

Drugs

Protein overload

Note: bence-jones globulins NOT detected on dipstick

Other

False Positives

  • Menses or other vaginal bleeding
  • Highly concentrated urine
  • Alkaline urine
  • Acetazolamide, cephalosporins, bicarb

See Also

Authors:

Claire