Difference between revisions of "Prothrombin complex concentrates"

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==See Also==
 
==See Also==
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*[[Blood transfusions]]
  
 
==Sources==
 
==Sources==

Revision as of 17:54, 28 May 2015

General

  • Type: Hemostatics, blood components
  • Dosage Forms:lypophilized concentrate for reconstitution 500u/vial and 1000u/vial
  • Common Trade Names: Kcentra

Adult Dosing

  • Based on pretreatment INR, units based on factor 9 content
    • INR2-<4: 25units/kg, not to exceed 2500 units
    • INR4-<6: 35units/kg, not to exceed 3500 units
    • INR>6: 50units/kg, not to exceed 5000 units

Pediatric Dosing

Safety and efficacy not established

Special Populations

  • Pregnancy Rating: C
  • Lactation: Unknown, breast feeding not advised
  • Renal Dosing
    • Adult-N/A
    • Pediatric-N/A
  • Hepatic Dosing
    • Adult-N/A
    • Pediatric-N/A

Contraindications

  • Allergy to class/drug
  • DIC
  • known HIT (Heparin induced thrombocytopenia)

Serious

  • thromboembolism
  • blood product (hepatitis, HIV)

Common

  • thromboembolic events (8.7%)
  • headache (7.8%)
  • hypotension (4.9%)
  • nausea/vomiting
  • arthralgia
  • ICH (2.9%)
  • mental status change (2.9%)
  • hypertension (2.9%)

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:
  • Mechanism of Action:

See Also

Sources

Medscape