Difference between revisions of "Prothrombin complex concentrates"

(Pharmacology)
(Post PCC, rechecking INR to guide additional management)
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**INR 4-6: 35units/kg, not to exceed 3500 units
 
**INR 4-6: 35units/kg, not to exceed 3500 units
 
**INR >6: 50units/kg, not to exceed 5000 units
 
**INR >6: 50units/kg, not to exceed 5000 units
 +
*Conisder rechecking INR after 15 minutes to determine need for redosing
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==

Revision as of 11:55, 6 May 2016

General

  • Type: Hemostatics, blood components
  • Dosage Forms:lypophilized concentrate for reconstitution 500u/vial and 1000u/vial
  • Common Trade Names: Kcentra

Adult Dosing

  • Based on pretreatment INR, units based on factor 9 content
    • INR 2-4: 25units/kg, not to exceed 2500 units
    • INR 4-6: 35units/kg, not to exceed 3500 units
    • INR >6: 50units/kg, not to exceed 5000 units
  • Conisder rechecking INR after 15 minutes to determine need for redosing

Pediatric Dosing

Safety and efficacy not established

Special Populations

  • Pregnancy Rating: C
  • Lactation: Unknown, breast feeding not advised
  • Renal Dosing
    • Adult-N/A
    • Pediatric-N/A
  • Hepatic Dosing
    • Adult-N/A
    • Pediatric-N/A

Contraindications

  • Allergy to class/drug
  • DIC
  • known HIT (Heparin induced thrombocytopenia)

Serious

  • thromboembolism
  • blood product (hepatitis, HIV)

Common

Pharmacology

  • Half-life: 4-60 hours, depending on clotting factor
  • Metabolism:
  • Excretion:
  • Mechanism of Action: 4 factor PCC contains factors II, VII, XI, X, protein C and S

See Also

References