Pyrazinamide

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Administration

  • Type: Antibiotic, anti-TB
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names:

Adult Dosing

  • 40-55 kg: 1000mg PO daily OR 1500mg PO 3 times per week OR 2000mg PO 2 times per week in combination with other agents
  • 56-75kg: 1500mg PO daily OR 2500mg PO 3 times per week OR 3000mg PO 2 times per week in combination with other agents
  • 76-90kg: 2000mg PO daily OR 3000mg PO 3 times per week OR 4000mg PO 2 times per week in combination with other agents

Pediatric Dosing

  • 15 to 30 mg/kg PO daily (max 2000mg/day) OR 50mg/kg PO 2 times per week in combination with other agents

Special Populations

  • Pregnancy Rating: C
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing, CrCl <30mL/min: 25-35mg/kg 3 times per week (after HD, if applicable)
  • Hepatic dosing: contraindicated in severe liver damage

Contraindications

  • Allergy to class/drug
  • Severe hepatic damage
  • Acute gout

Adverse Reactions

Serious

  • Hepatotoxicity
  • Anemia

Common

  • Nausea/vomiting
  • Arthralgia
  • Hyperuricemia

Pharmacology

  • Half-life: 6.7-12.3h, longer in cirrhosis and/or ESRD
  • Metabolism: hepatic
  • Excretion: Mostly renal

Mechanism of Action

  • Nicotinamide analogue, exact antitubercular mechanism unknown

Comments

See Also

References