Ritonavir: Difference between revisions
No edit summary |
No edit summary |
||
Line 78: | Line 78: | ||
==Mechanism of Action== | ==Mechanism of Action== | ||
*Binds to active site of HIV protease, preventing maturation of the virus | |||
==Comments== | ==Comments== |
Revision as of 12:33, 22 March 2020
Administration
- Type: Antiviral
- Dosage Forms: 100 mg
- Routes of Administration: PO
- Common Trade Names: Norvir
Adult Dosing
- HIV Treatment
- HIV post-exposure prophylaxis
Pediatric Dosing
- HIV Treatment
- HIV post-exposure prophylaxis
Special Populations
Pregnancy Rating
- HIV: Benefits outweight risk during pregnancy. Avoid oral solution due to alcohol content.
Lactation risk
- Avoid breastfeeding
Renal Dosing
- Adult: No adjustment
- Pediatric: Not defined, but likely no adjustment as in adults
Hepatic Dosing
- Adult:
- Mild-moderate impairment: no adjustment
- Severe impairment: not defined
- Pediatric:
- Mild-moderate impairment: no adjustment
- Severe impairment: not defined
Contraindications
- Allergy to class/drug
Adverse Reactions
Serious
- Hepatotoxicity
- Pancreatitis
- GI bleed
- Hypersensitivity reaction
- Anaphylaxis
- Toxic epidermal necrolysis
- Stevens-Johnson syndrome
- PR prolongation/AV block
- Hypercholesterolemia/hypertriglyceridemia
- Diabetes mellitus/hyperglycemia
- Immune reconstitution syndrome
- Autoimmune disorders
- Hypertension
- Syncope
- Orthostatic hypotension
- Myopathy
- Thrombocytopenia
Common
- Nausea/vomiting
- Diarrhea
- Paresthesia
- Fatigue
- Rash
- Abdominal pain
- Cough
- Dysgeusia
- Oropharyngeal pain
- Dizziness
- AST, ALT, CK elevation
- Edema
- Acne
- Lipodystrophy
Pharmacology
- Half-life: 3-5 hours
- Metabolism: Liver (CYP450)
- Excretion: Fecal
Mechanism of Action
- Binds to active site of HIV protease, preventing maturation of the virus