Difference between revisions of "SSRI toxicity"

(Text replacement - "==Treatment==" to "==Management==")
(Clinical Features)
Line 11: Line 11:
 
*QRS, [[QT prolongation]] (citalopram only)
 
*QRS, [[QT prolongation]] (citalopram only)
 
*[[Serotonin syndrome]]
 
*[[Serotonin syndrome]]
 +
*Coma and seizures (rare)
  
 
==Differential Diagnosis==
 
==Differential Diagnosis==

Revision as of 14:18, 1 September 2019

Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes

Management

  • GI decontamination
    • Activated charcoal x1
    • Gastric lavage unnecessary

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion

See Also

References

  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.