Difference between revisions of "SSRI toxicity"

(Clinical Features)
(Management)
Line 18: Line 18:
  
 
==Management==
 
==Management==
*GI decontamination
+
*Supportive care
**Activated charcoal x1
+
*No role for activated charcoal or gastric lavage
**Gastric lavage unnecessary
+
*Magnesium sulfate 2g IV if QTc > 500 msec
 +
*IV benzodiazepines if agitation or seizures
  
 
==Disposition==
 
==Disposition==

Revision as of 14:21, 1 September 2019

Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes

Management

  • Supportive care
  • No role for activated charcoal or gastric lavage
  • Magnesium sulfate 2g IV if QTc > 500 msec
  • IV benzodiazepines if agitation or seizures

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion

See Also

References

  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.