Difference between revisions of "SSRI toxicity"

(Redirected page to Serotonin syndrome)
 
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#REDIRECT[[Serotonin syndrome]]
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==Background==
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*Most serious adverse effect is potential to produce [[Serotonin Syndrome]]
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*Fatalities are uncommon with pure overdoses
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==Clinical Features==
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*[[Nausea and vomiting]]
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*Sedation
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*Tremor
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*[[Sinus tachycardia]]
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*QRS, [[QT prolongation]] (citalopram only)
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*[[Serotonin syndrome]]
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*[[Coma]] and [[seizures]] (rare)
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==Differential Diagnosis==
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*[[Serotonin syndrome]]
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{{Anticholinergic types}}
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==Management==
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*Supportive care
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*No role for [[activated charcoal]] or gastric lavage
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*[[Magnesium]] sulfate 2g IV if QTc > 500 msec
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*IV [[benzodiazepines]] if agitation or seizures
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==Disposition==
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*Consider admission for patients who are tachycardic or lethargic 6hr after ingestion
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*ECG before clearing a patient with citalopram ingestion
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==See Also==
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*[[Serotonin syndrome]]
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*[[SNRI Toxicity]]
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==References==
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<references/>
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[[Category:Toxicology]]

Latest revision as of 14:32, 1 September 2019

Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes

Management

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingestion
  • ECG before clearing a patient with citalopram ingestion

See Also

References

  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.