Difference between revisions of "SSRI toxicity"

(Text replacement - "Category:Tox" to "Category:Toxicology")
 
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*QRS, [[QT prolongation]] (citalopram only)
 
*QRS, [[QT prolongation]] (citalopram only)
 
*[[Serotonin syndrome]]
 
*[[Serotonin syndrome]]
 +
*[[Coma]] and [[seizures]] (rare)
  
 
==Differential Diagnosis==
 
==Differential Diagnosis==
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{{Anticholinergic types}}
 
{{Anticholinergic types}}
  
==Treatment==
+
==Management==
*GI decontamination
+
*Supportive care
**Activated charcoal x1
+
*No role for [[activated charcoal]] or gastric lavage
**Gastric lavage unnecessary
+
*[[Magnesium]] sulfate 2g IV if QTc > 500 msec
 +
*IV [[benzodiazepines]] if agitation or seizures
  
 
==Disposition==
 
==Disposition==
*Consider admission for patients who are tachycardic or lethargic 6hr after ingesion
+
*Consider admission for patients who are tachycardic or lethargic 6hr after ingestion
 +
*ECG before clearing a patient with citalopram ingestion
  
 
==See Also==
 
==See Also==
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*[[SNRI Toxicity]]
 
*[[SNRI Toxicity]]
  
==Source==
+
==References==
Tintinalli
+
<references/>
 +
 
  
 
[[Category:Toxicology]]
 
[[Category:Toxicology]]

Latest revision as of 14:32, 1 September 2019

Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes

Management

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingestion
  • ECG before clearing a patient with citalopram ingestion

See Also

References

  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.