Difference between revisions of "SSRI toxicity"

(Clinical Features)
Line 5: Line 5:
  
 
==Clinical Features==
 
==Clinical Features==
*N/V
+
*[[Nausea and vomiting]]
 
*Sedation
 
*Sedation
 
*Tremor
 
*Tremor
*Sinus Tachycardia
+
*[[Sinus tachycardia]]
*QRS, QT prolongation (citalopram only)
+
*QRS, [[QT prolongation]] (citalopram only)
*[[Serotonin Syndrome]]
+
*[[Serotonin syndrome]]
 +
 
 +
==Differential Diagnosis==
 +
*[[Serotonin syndrome]]
 +
{{Anticholinergic types}}
  
 
==Treatment==
 
==Treatment==

Revision as of 03:24, 16 December 2014

Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

Differential Diagnosis

Anticholinergic toxicity Causes

Treatment

  • GI decontamination
    • Activated charcoal x1
    • Gastric lavage unnecessary

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion

See Also

Source

Tintinalli

  1. Dawson AH, Buckley NA. Pharmacological management of anticholinergic delirium – theory, evidence and practice. Br J Clin Pharmacol. 2015;81(3):516-24.