Selective serotonin reuptake inhibitor toxicity

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

  • N/V
  • Sedation
  • Tremor
  • Sinus Tachycardia
  • QRS, QT prolongation (citalopram only)
  • Serotonin Syndrome

Treatment

  • GI decontamination
    • Activated charcoal x1
    • Gastric lavage unnecessary

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion

See Also

Source

Tintinalli