Selective serotonin reuptake inhibitor toxicity

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Background

  • Most serious adverse effect is potential to produce Serotonin Syndrome
  • Fatalities are uncommon with pure overdoses

Clinical Features

  • N/V
  • Sedation
  • Tremor
  • Sinus Tachycardia
  • QRS, QT prolongation (citalopram only)
  • Serotonin Syndrome

Treatment

  • GI decontamination
    • Activated charcoal x1
    • Gastric lavage unnecessary

Disposition

  • Consider admission for patients who are tachycardic or lethargic 6hr after ingesion

Source

Tintinalli

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