Strychnine

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Background

  • Strychnine is a highly toxic substance, mimics generalized tetanus
  • Antagonizes glycine release, but unlike TS, it has no effect on GABA release
  • Gopher poison classically

Clinical Features

Differential Diagnosis

  • Black widow spider bite
  • Stiff-man syndrome

Movement Disorders and Other Abnormal Contractions

Jaw Spasms

Evaluation

  • Serum and urine tests for strychnine

Management

Disposition

  • All patients should be admitted

See Also

References