Succimer

Administration

• Type: Antidote
• Dosage Forms: Capsule 100mg
• Routes of Administration: Oral
• Common Trade Names: Chemet

Adult Dosing

Lead poisoning

• 10 to 30 mg/kg/day for 5 days

Pediatric Dosing

Safety/efficacy not established in patients <12mo

• Lead poisoning, level >45 mcg/dL: 10 mg/kg or 350 mg/m(2) q8h for 5 days, then q12 h for 14 days

Special Populations

• Pregnancy Rating: C
• Lactation risk: Avoid breastfeeding during treatment and for at least 5 days after d/c. Possible risk of infant toxicity
• Renal dosing: administer with caution, ensure adequate hydration
• Hepatic dosing: no adjustment, monitor LFTs closely

Contraindications

• Allergy to class/drug
• Breastfeeding during treatment and five days after d/c
• ANC < 1200

Adverse Reactions

Serious

• Neutropenia
• Arrhythmia

Common

• Rash
• Nausea/vomiting, diarrhea, decreased appetite
• Elevated transaminases

Pharmacology

• Half-life: 48h
• Metabolism: Site unknown
• Excretion: Renal 25%, feces 39%, lungs 1%

Mechanism of Action

• Forms stable, water-soluble complexes with lead, leading to increased urinary excretion

See Also

• Antidotes
• Lead toxicity
• EDTA, Dimercaprol