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==Administration==
*Type: Ergotamine anti-migraine drug
*Dosage Forms:
*Routes of Administration: Intranasal, oral, subcutanous, transdermal
*Common Trade Names: Imitrex

==Adult Dosing==
*Intranasal spray: 5-20 mg, may repeat dose if headache persists after 2 hours
*Oral: Initial: 50 to 100 mg once. If initial dose was partially effective or headache recurs, may repeat a dose (usually same as first dose) after ≥2 hours. Maximum dose: 100 mg per dose; 200 mg per 24 hours.

==Pediatric Dosing==
*Intranasal: 
**5-17 years: 5mg-20mg administered in one nostril as a single dose
*SubQ:
**6-17 years: 3-6mg single dose 
*Efficacy of oral dosing has not been demonstrated in patients <17 years old.

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: infant risk minimal
*Renal dosing: no adjustment
*Hepatic dosing: contraindicated in severe hepatic impairment

==Contraindications==
*Allergy to class/drug
*MAOI use concomitantly or within 2 weeks
*Concomitant use of ergotamine-containing/ergot-type medication within 24 hours
*Use of another 5-HT agonist within 24 hours
*History of cardiovascular (including arrythmias, CAD, uncontrolled hypertension), peripheral vascular, or ischemic bowel disease
*History of stroke/TIA or hemiplegic/basilar migraine
*Severe hepatic impairment

==Adverse Reactions==
===Serious===
*[[MI]], [[hypertensive crisis]], ventricular arrhythmias, vasospasm
*[[Serotonin syndrome]]
*[[Stroke]], [[intracranial hemorrhage]], [[seizure]]
*[[Visual loss]]

===Common===
*[[Dizziness]]
*[[Nausea/vomiting]]
*[[URI]] symptoms

==Pharmacology==
*Half-life: 2-3 hours
*Metabolism: Hepatic via monamine oxidase (mostly MAO-A)
*Excretion: mostly renal

==Mechanism of Action==
*Cranial vessel constriction, 5HT agonist, inhibition of pro-inflammatory neuropeptide release
==Comments==

==See Also==
*[[Headache]]
*[[Serotonin syndrome]]
==References==
<references/>
[[Category:Pharmacology]]