Synthetic cannabinoids: Difference between revisions
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==Background== | ==Background== | ||
*Common names: spice, K2, Moon Rocks, Blue Lotus, many others | *Common names: spice, K2, Moon Rocks, Blue Lotus, many others | ||
*Active ingredients: cannabicyclohexano, JWH-018, JWH-073, HU-210, others | *Active ingredients: cannabicyclohexano, JWH-018, JWH-073, HU-210, XLR-11, others | ||
*Far more potent than THC (100-800x) | *Far more potent than THC (100-800x) | ||
*Cannabinoid receptor agonists (CB1 or CB2) | *Cannabinoid receptor agonists (CB1 or CB2) | ||
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*'''Tachycardia and hypertension''' common (distinguishing it from MJ use) | *'''Tachycardia and hypertension''' common (distinguishing it from MJ use) | ||
*Adverse effects: nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli | *Adverse effects: nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli | ||
*Use has been associated with AKI and acute cerebral ischemia.<ref>Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.</ref><ref>Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.</ref> | |||
==Treatment== | ==Treatment== | ||
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==Source== | ==Source== | ||
David Burbulys, MD lecture 9/2012 | David Burbulys, MD lecture 9/2012 | ||
<references/> | |||
[[Category:Tox]] | [[Category:Tox]] | ||
Revision as of 18:03, 30 October 2014
Background
- Common names: spice, K2, Moon Rocks, Blue Lotus, many others
- Active ingredients: cannabicyclohexano, JWH-018, JWH-073, HU-210, XLR-11, others
- Far more potent than THC (100-800x)
- Cannabinoid receptor agonists (CB1 or CB2)
- Do not show up as marijuana on routine tox testing
- Generally smoked, but can be drank as a tea
Clinical Features
- Similar effect to marijuana at low doses, but may be more intense and cause an acute agitated delerium
- Typical effects 10-30 min and taper over 1-2 hours
- Tachycardia and hypertension common (distinguishing it from MJ use)
- Adverse effects: nausea, vomiting, diaphoresis, anxiety, paranoia, hallucinations, agitation, deli
- Use has been associated with AKI and acute cerebral ischemia.[1][2]
Treatment
- Supportive
- Benzodiazepines
- Zofran
Source
David Burbulys, MD lecture 9/2012
- ↑ Buser GL, Gerona RR, Horowitz BZ, et al. Acute kidney injury associated with smoking synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(7):664–73.
- ↑ Takematsu M, Hoffman RS, Nelson LS, Schechter JM, Moran JH, Wiener SW. A case of acute cerebral ischemia following inhalation of a synthetic cannabinoid. Clin Toxicol (Phila). 2014;52(9):973–5.