Difference between revisions of "Systemic lupus erythematosus"

(Clinical Features)
(changed diagnostic criteria)
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==Clinical Features==
 
==Clinical Features==
'''Diagnostic Criteria:'''
+
'''SLICC Classification Criteria 2012''' <ref>Lisnevskaia L, et al. Systemic Lupus Erythematosus. Lancet. 2014 May 29. Epub ahead of print.</ref>
4 out of 11 of the following:
+
 
#Malar rash
+
Requirements: >4 of the following criteria (at least 1 clinical and 1 laboratory) '''OR''' biopsy proven lupus nephritis with
#Discoid rash
+
positive ANA or Anti-dsDNA
#Photosensitivity
+
*Clinical criteria
#Oral ulcers
+
**Malar rash, bullous lupus, photosensitivity
#Arthritis (polyarticular)
+
**Discoid rash, hypertrophic lupus
#Serositis (Pericarditis or pleuritis)
+
**Oral ulcers or nasal ulcers
#Renal disorder (renal failure, protenuria, casts)
+
**Non-scarring alopecia
#Neurologic or psychotic symptoms
+
**Synovitis
#Hematologic (anemia, thrombocytopenia, or leukopenia)
+
**Serositis
#Immunologic (+antibofy testing)
+
**Nephritis
#ANA (positive ANA)
+
**Cerebritis, myelitis, neuropathy
 +
**Hemolytic anemia
 +
**Leukopenia or lymphopenia
 +
**Thrombocytopenia
 +
 
 +
*Immunological criteria
 +
 
 +
**ANA
 +
**Anti-dsDNA
 +
**Anti-Sm
 +
**Antiphospholipid antibody
 +
**Low complement C3, low C4
 +
**Direct Coombs' test in the absence of haemolytic anaemia
  
 
'''Organ system affected:'''
 
'''Organ system affected:'''

Revision as of 19:23, 13 June 2014

Background

  • Autoimmune disorder affecting all systems

Epidemiology

  • Female:Male 10:1
  • Peak in 20s-30s
  • More common in African Americans


Clinical Features

SLICC Classification Criteria 2012 [1]

Requirements: >4 of the following criteria (at least 1 clinical and 1 laboratory) OR biopsy proven lupus nephritis with positive ANA or Anti-dsDNA

  • Clinical criteria
    • Malar rash, bullous lupus, photosensitivity
    • Discoid rash, hypertrophic lupus
    • Oral ulcers or nasal ulcers
    • Non-scarring alopecia
    • Synovitis
    • Serositis
    • Nephritis
    • Cerebritis, myelitis, neuropathy
    • Hemolytic anemia
    • Leukopenia or lymphopenia
    • Thrombocytopenia
  • Immunological criteria
    • ANA
    • Anti-dsDNA
    • Anti-Sm
    • Antiphospholipid antibody
    • Low complement C3, low C4
    • Direct Coombs' test in the absence of haemolytic anaemia

Organ system affected:

  • Musculoskeletal
    • Arthritis
      • Usually symmetric
      • Consider septic arthritis if there is a single inflamed joint
        • Cover for Salmonella in addition to standard coverage
  • GI
    • Lupus enteritis (mesenteric vasculitis)
      • Most common cause of acute abdominal pain
    • Pancreatitis
    • PUD
  • Dermatologic
    • Malar rash across bridge of nose
    • Discoid rash, erythematous with scale
    • Treat with topical 1% hydrocortisone
  • Renal
    • Usually a nephritis
    • Can cause a glomerulonephrosis

Differential Diagnosis

Workup

Undiagnosed

  • CBC
  • Chem 10
  • Urine pregnancy
  • ANA
  • ESR
  • UA
  • Bedside echo if ill or hypotensive
  • (Consider anti-DNA, anti-Smith, anti-Nuclear, anti-phospholipid, C3,C4, direct Coombs')

Flare

  • Bedside echo if ill or hypotensive
  • CBC
  • Chem
  • UA
  • Urine pregnancy
  • As directed by organ system involved

Management

  • Inflammatory complications
    • Methylprednisolone 1-2mg/kg in most cases
  • Infectious
    • Stress dose steroids with hydrocortisone 100mg IV Q8hr if on or recently on steroids
  • Dermatologic
    • Hydrocortisone 1% cream

Disposition

  • Suspected new diagnosis can have out patient workup if well appearing
  • Mild flairs can have expedited out patient management
  • Musculoskeletal symptoms can usually be managed as out patients
  • Chest pain requires urgent ACS evaluation
  • Infections usually require admission for antibiotics and systemic corticosteroids

See Also

Sources

  • Rosen's
  • Up to date
  1. Lisnevskaia L, et al. Systemic Lupus Erythematosus. Lancet. 2014 May 29. Epub ahead of print.