Systemic lupus erythematosus

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Background

  • Autoimmune disorder affecting all sysems

Epidemiology

  • Femaile:Male 10:1
  • More common in African Americans


Clinical Features

Diagnostic Criteria: 4 out of 11 of the following:

  1. Malar rash
  2. Discoid rash
  3. Photosensitivity
  4. Oral ulcers
  5. Arthritis (polyarticular)
  6. Serositis (Pericarditis or pleuritis)
  7. Renal disorder (renal failure, protenuria, casts)
  8. Neurologic or psychotic symptoms
  9. Hematologic (anemia, thrombocytopenia, or leukopenia)
  10. Immunologic (+antibofy testing)
  11. ANA (positive ANA)

New Presentations


Flairs

  • Neuropsychartic/Altered mental status


  • Musculoskeletal


Differential Diagnosis

Workup

Undiagnosed

  • CBC
  • Chem 10
  • ANA
  • ESR
  • UA
  • Bedside echo if ill or hypotensive

Flair

  • Bedside echo if ill or hypotensive
  • CBC



Management

  • Steroids


Disposition

See Also

Arthritis Fever and Rash Lupus Anticoagulant Pericarditis Pericardial Effusion and Tamponade Acute Renal Failure Adrenal Crisis


Sources

  • Rosen's
  • Up to date