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<p>Creation of page</p>
<p><b>New page</b></p><div>==Administration==<br />
*Type: [[Benzodiazepine]]<br />
*Dosage Forms: Cap 7.5mg, 15mg, 22.5mg, 30mg<br />
*Routes of Administration: Oral<br />
*Common Trade Names: Restoril<br />
<br />
==Adult Dosing==<br />
===[[Insomnia]]===<br />
*15mg PO qhs<br />
**Start 7.5mg PO qhs in elderly patients<br />
===Sleep terrors===<br />
*15-30mg PO qhs<br />
<br />
==Pediatric Dosing==<br />
Safety/efficacy not established in pediatric patients<br />
<br />
==Special Populations==<br />
===[[Drug pregnancy categories|Pregnancy Rating]]===<br />
*Consider alternatives during pregnancy<br />
*Risk of neonatal withdrawal symptoms and floppy infant syndrome<br />
<br />
===Lactation risk===<br />
*May use low doses short-term when breastfeeding<br />
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===Renal Dosing===<br />
*Adult: No adjustment<br />
*Pediatric: Not defined<br />
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===Hepatic Dosing===<br />
*Adult: No adjustment<br />
*Pediatric: Not defined<br />
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==Contraindications==<br />
*Allergy to class/drug<br />
*Pregnancy<br />
*Avoid abrupt withdrawal with long term use<br />
<br />
==Adverse Reactions==<br />
===Serious===<br />
*[[Anaphylaxis]], [[angioedema]]<br />
*Respiratory depression<br />
*Dependency<br />
*[[Seizure]]<br />
*Suicidality<br />
*[[Tachycardia]], [[hypotension]], [[syncope]]<br />
<br />
===Common===<br />
*Drowsiness, fatigue<br />
*[[Dizziness]]<br />
*[[Anxiety]], [[Amnesia]], confusion<br />
*Disinhibition<br />
*Dystonia. [[Dysarthria]], diplopia<br />
*Incontinence, constipation<br />
*[[Rash]]<br />
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==Pharmacology==<br />
*Half-life: 8.8h<br />
*Metabolism: Liver<br />
*Excretion: Urine 80-90%<br />
<br />
==Mechanism of Action==<br />
*Binds to [[benzodiazepine]] receptors to enhance GABA effects<br />
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==Comments==<br />
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==See Also==<br />
[[Benzodiazepine]]<br />
<br />
==References==<br />
<references/><br />
<br />
[[Category:Pharmacology]]</div>
Jonwarren