Difference between revisions of "Tigecycline"

(Text replacement - "Category:Drugs" to "Category:Pharmacology")
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==General==
 
==General==
*Type:  
+
*Type: [[Glycylcycline]] ([[Tetracyclines]])
 
*Dosage Forms:
 
*Dosage Forms:
*Common Trade Names:  
+
*Common Trade Names: Tygacil
  
 
==Adult Dosing==
 
==Adult Dosing==
 +
===General Infections===
 +
*
  
 
==Pediatric Dosing==
 
==Pediatric Dosing==
 +
===General Infections===
 +
*
  
 
==Special Populations==
 
==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]:
+
*[[Drug Ratings in Pregnancy|Drug rating in pregnancy]]:  
*Lactation:
+
*[[Lactation_risk_categories|Lactation risk category]]: Lactation: Possibly Unsafe; consider alternatives
 
*Renal Dosing
 
*Renal Dosing
**Adult
+
**Adult:
**Pediatric
+
**Pediatric:
 
*Hepatic Dosing
 
*Hepatic Dosing
**Adult
+
**Adult:
**Pediatric
+
**Pediatric:
 +
*
  
 
==Contraindications==
 
==Contraindications==
 
*Allergy to class/drug
 
*Allergy to class/drug
 +
*Pregnancy
 +
*Age <8 years
 +
*Caution:
 +
**Child bearing potential
 +
**
 +
*
  
 
==Adverse Reactions==
 
==Adverse Reactions==
 
===Serious===
 
===Serious===
 +
*Tooth discoloration children <8 years old
 +
*Photosensitivity
 +
*Hypersensitivity reaction
 +
*Skin reaction
 +
*Vasculitis
 +
*Pericarditis
 +
*Autoimmune hepatitis
 +
*Hepatotoxicity
 +
*Nephrotoxicity
 +
*Esophagitis/ulcer
 +
*[[Pancreatitis]]
 +
*[[Thrombocytopenia]]
 +
*[[Neutropenia]]
 +
*Hemolytic anemia
 +
*[[Pseudotumor cerebri]]
 +
*Bulging fontanelles
 +
*Jarisch-Herxheimer reaction
 +
*Fetal harm
  
 
===Common===
 
===Common===
 +
*Headache
 +
*Nausea
 +
*Dyspepsia
 +
*Arthralgia
 +
*Diarrhea
 +
*Rash
 +
*Dysmenorrhea
 +
*Photosensitivity
 +
*Vulvovaginal candidiasis
 +
*Skin discoloration
 +
*Elevated BUN
  
 
==Pharmacology==
 
==Pharmacology==
 
*Half-life:  
 
*Half-life:  
 
*Metabolism:  
 
*Metabolism:  
*Excretion:  
+
*Excretion: Feces and urine
*Mechanism of Action:
+
*Mechanism of Action: Bacteriostatic
  
 
==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
 
==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==

Revision as of 12:26, 30 March 2016

General

Adult Dosing

General Infections

Pediatric Dosing

General Infections

Special Populations

Contraindications

  • Allergy to class/drug
  • Pregnancy
  • Age <8 years
  • Caution:
    • Child bearing potential

Adverse Reactions

Serious

  • Tooth discoloration children <8 years old
  • Photosensitivity
  • Hypersensitivity reaction
  • Skin reaction
  • Vasculitis
  • Pericarditis
  • Autoimmune hepatitis
  • Hepatotoxicity
  • Nephrotoxicity
  • Esophagitis/ulcer
  • Pancreatitis
  • Thrombocytopenia
  • Neutropenia
  • Hemolytic anemia
  • Pseudotumor cerebri
  • Bulging fontanelles
  • Jarisch-Herxheimer reaction
  • Fetal harm

Common

  • Headache
  • Nausea
  • Dyspepsia
  • Arthralgia
  • Diarrhea
  • Rash
  • Dysmenorrhea
  • Photosensitivity
  • Vulvovaginal candidiasis
  • Skin discoloration
  • Elevated BUN

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion: Feces and urine
  • Mechanism of Action: Bacteriostatic

Antibiotic Sensitivities[1]

Group Organism Sensitivity
Gram Positive Strep. Group A, B, C, G S
Strep. Pneumoniae S
Viridans strep X1
Strep. anginosus gp X1
Enterococcus faecalis S
Enterococcus faecium S
MSSA S
MRSA S
CA-MRSA S
Staph. Epidermidis S
C. jeikeium S
L. monocytogenes S
Gram Negatives N. gonorrhoeae X2
N. meningitidis X1
Moraxella catarrhalis S
H. influenzae S
E. coli S
Klebsiella sp S
E. coli/Klebsiella ESBL+ S
E coli/Klebsiella KPC+ S
Enterobacter sp, AmpC neg S
Enterobacter sp, AmpC pos S
Serratia sp X1
Serratia marcescens S
Salmonella sp S
Shigella sp S
Proteus mirabilis X1
Proteus vulgaris I
Providencia sp. X1
Morganella sp. X1
Citrobacter freundii X1
Citrobacter diversus X1
Citrobacter sp. X1
Aeromonas sp X1
Acinetobacter sp. I
Pseudomonas aeruginosa R
Burkholderia cepacia I
Stenotrophomonas maltophilia S
Yersinia enterocolitica X1
Francisella tularensis X1
Brucella sp. X1
Legionella sp. X2
Pasteurella multocida X1
Haemophilus ducreyi X1
Vibrio vulnificus X1
Misc Chlamydophila sp S
Mycoplasm pneumoniae S
Rickettsia sp X1
Mycobacterium avium R
Anaerobes Actinomyces X1
Bacteroides fragilis S
Prevotella melaninogenica S
Clostridium difficile X1
Clostridium (not difficile) S
Fusobacterium necrophorum S
Peptostreptococcus sp. S

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

See Also

Source

  1. Sanford Guide to Antimicrobial Therapy 2014