Tizanidine

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Administration

  • Type: Muscle relaxant
  • Dosage Forms: Cap: 2mg, 4mg; Tab: 2mg, 4mg
  • Routes of Administration: Oral
  • Common Trade Names: Zanaflex

Adult Dosing

Spasticity

  • Individualize dose PO q6-8h prn
    • Start 2mg PO x1
    • Max: 3 doses/24h up to 36mg/day
    • Taper dose 2-4 mg/day to D/C if prolonged use

Pediatric Dosing

Safety/efficacy not established in pediatric patients

Special Populations

Pregnancy Rating

  • Consider alternative during pregnancy
  • Possible risk of fetal harm

Lactation risk

  • Consider alternative while breastfeeding
  • Possible risk of infant sedation and hypotension

Renal Dosing

  • Adult: CrCl <25: Decrease dose

Hepatic Dosing

  • Adult: Not defined

Contraindications

  • Allergy to class/drug
  • Avoid abrupt withdrawal

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life: 2.5 hr
  • Metabolism: Liver; CYP450: 1A2 substrate
  • Excretion: Urine 60%, feces 20%

Mechanism of Action

  • Binds to central alpha-2 adrenergic receptors, increasing presynaptic motor neuron inhibition and reducing spasticity
  • Centrally acting

Comments

See Also

References