Topiramate: Difference between revisions
(Text replacement - "5 mg" to "5mg")
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===Partial Seizures===
===Partial Seizures===
*monotherapy
*monotherapy
**Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, increase by 50 mg/day qwk until 100 mg PO bid, then increase by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
**Dose: 200 mg PO bid; Start: 25mg PO bid x1wk, increase by 50 mg/day qwk until 100 mg PO bid, then increase by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
*adjunct therapy
*adjunct therapy
**Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective
**Dose: 100-200 mg PO bid; Start: 25mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective


===seizures, primary generalized tonic clonic===
===seizures, primary generalized tonic clonic===
*monotherapy
*monotherapy
**Dose: 200 mg PO bid; Start: 25 mg PO bid x1wk, increase by 50 mg/day qwk until 100 mg PO bid, then increase by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
**Dose: 200 mg PO bid; Start: 25mg PO bid x1wk, increase by 50 mg/day qwk until 100 mg PO bid, then increase by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
*adjunct therapy
*adjunct therapy
**Dose: 200 mg PO bid; Start: 25 mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective
**Dose: 200 mg PO bid; Start: 25mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective


===Seizures, Lennox-Gastaut===
===Seizures, Lennox-Gastaut===
*adjunct therapy
*adjunct therapy
**Dose: 100-200 mg PO bid; Start: 25 mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective
**Dose: 100-200 mg PO bid; Start: 25mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective


===Migraine headache, prophylaxis===
===Migraine headache, prophylaxis===
*50 mg PO bid
*50 mg PO bid
**Start: 25 mg PO qhs x1wk, increase by 25 mg/day qwk; Max: 200 mg/day
**Start: 25mg PO qhs x1wk, increase by 25mg/day qwk; Max: 200 mg/day


==Pediatric Dosing==
==Pediatric Dosing==

Revision as of 04:17, 21 July 2016

Administration

  • Type: anti epileptic
  • Dosage Forms: 25,50,100,200 tabs; 15,25 caps
  • Routes of Administration: PO
  • Common Trade Names: Topamax

Adult Dosing

Partial Seizures

  • monotherapy
    • Dose: 200 mg PO bid; Start: 25mg PO bid x1wk, increase by 50 mg/day qwk until 100 mg PO bid, then increase by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
  • adjunct therapy
    • Dose: 100-200 mg PO bid; Start: 25mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective

seizures, primary generalized tonic clonic

  • monotherapy
    • Dose: 200 mg PO bid; Start: 25mg PO bid x1wk, increase by 50 mg/day qwk until 100 mg PO bid, then increase by 100 mg/day qwk; Info: doses >400 mg/day rarely more effective
  • adjunct therapy
    • Dose: 200 mg PO bid; Start: 25mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective

Seizures, Lennox-Gastaut

  • adjunct therapy
    • Dose: 100-200 mg PO bid; Start: 25mg PO qd-bid x1wk, increase by 25-50 mg/day qwk; Info: doses >400 mg/day rarely more effective

Migraine headache, prophylaxis

  • 50 mg PO bid
    • Start: 25mg PO qhs x1wk, increase by 25mg/day qwk; Max: 200 mg/day

Pediatric Dosing

Special Populations

Renal Dosing

  • Adult: CrCl 10-70: decrease dose 50%; CrCl <10: decrease dose 75%; HD: give supplement
  • Pediatric:

Hepatic Dosing

  • Adult: not defined; caution advised
  • Pediatric:

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

Common

Pharmacology

  • Half-life:
  • Metabolism:
  • Excretion:

Mechanism of Action

Comments

See Also

References

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