Difference between revisions of "Tranexamic acid"

(See Also)
(See Also)
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*[[Transfusions]]
 
*[[Transfusions]]
 
*[[Transfusion Reactions]]
 
*[[Transfusion Reactions]]
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==External Links==
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*[http://www.emcurious.com/blog-1/2014/7/11/bcej55h3s3rk93uekwtvw9biixn0y8 EMCurious - TXA Trauma Lit Review]
  
 
==Source==
 
==Source==

Revision as of 01:31, 15 July 2014

Background

  • Action: Antifibrinolytic agent
  • Availability:
    • Ampule of 1 Gm in 10 mL

Indication

Severely bleeding trauma patient, systolic blood pressure of <90 and/or heart rate > 110 beats/min., with expected requirement for massive transfusion.

Contraindication/Exclusion Criteria

  • Greater than 3 hours from injury
  • Known sensitivity to TXA
  • Previous DVT or Pulmonary Embolism

Administration

  • Adult dose- Total of 2 Gms
    • Initial bolus of 1 Gm over 10 minutes (Slow IV push). Draw up with filter needle.
    • Maintenance: additional 1 Gm over next 8 hours (mix in 50 mL of NS). Call Pharmacy to mix and deliver the continuous infusion.
  • Pediatric dose- (weight based)
    • Initial bolus of 20 mg/kg IV Bolus over 10 minutes
    • Maintenance: 10 mL/kg/hr over next 8 hours

No additional laboratory tests required.

Adverse Reactions

  • Thrombotic events
  • Hypotension with rapid injection
  • Nausea, vomiting, diarrhea
  • Impaired color vision and other visual disturbances

See Also

External Links

Source

Harbor-UCLA Tranexamic Acid (TXA) Guidelines for Administration in Trauma