Difference between revisions of "Transfusion-related acute lung injury"

(Created page with "==Background== ==Clinical Features== ==Differential Diagnosis== {{Transfusion reaction types}} ==Diagnosis== ==Management== ==Disposition== ==See Also== *Transfusion r...")
 
Line 1: Line 1:
 
==Background==
 
==Background==
 +
*Due to granulocyte recruitment and degranulation within the lung
 +
*More common with [[FFP]] and [[platelet]] transfusions (extremely rare with [[pRBC]] transfusion alone)
 +
**[[pRBCs]] do contain residual plasma and can have TRALI
  
 
==Clinical Features==
 
==Clinical Features==
 +
*[[ARDS]]-like symptoms
  
 
==Differential Diagnosis==
 
==Differential Diagnosis==
Line 7: Line 11:
  
 
==Diagnosis==
 
==Diagnosis==
 +
*Time Frame: abrupt to within 6 hours of transfusion initiation
  
 
==Management==
 
==Management==
 +
**Strop transfusion
 +
**Treat like [[ARDS]]
 +
**Avoid diuresis
  
 
==Disposition==
 
==Disposition==
 +
*Bilateral pulmonary infiltrates due to noncardiogenic pulmonary edema within 6h of transfusion
  
 
==See Also==
 
==See Also==

Revision as of 20:56, 4 February 2016

Background

  • Due to granulocyte recruitment and degranulation within the lung
  • More common with FFP and platelet transfusions (extremely rare with pRBC transfusion alone)
    • pRBCs do contain residual plasma and can have TRALI

Clinical Features

Differential Diagnosis

Transfusion Reaction Types

Diagnosis

  • Time Frame: abrupt to within 6 hours of transfusion initiation

Management

    • Strop transfusion
    • Treat like ARDS
    • Avoid diuresis

Disposition

  • Bilateral pulmonary infiltrates due to noncardiogenic pulmonary edema within 6h of transfusion

See Also

External Links

References