Difference between revisions of "Transfusion-related acute lung injury"

Line 1: Line 1:
 
==Background==
 
==Background==
 
*Due to granulocyte recruitment and degranulation within the lung
 
*Due to granulocyte recruitment and degranulation within the lung
*More common with [[FFP]] and [[platelet]] transfusions (extremely rare with [[pRBC]] transfusion alone)
+
*More common with [[FFP]] and [[platelet transfusion]]s (extremely rare with [[pRBC]] transfusion alone)
 
**[[pRBCs]] do contain residual plasma and can have TRALI
 
**[[pRBCs]] do contain residual plasma and can have TRALI
  

Revision as of 20:56, 4 February 2016

Background

  • Due to granulocyte recruitment and degranulation within the lung
  • More common with FFP and platelet transfusions (extremely rare with pRBC transfusion alone)
    • pRBCs do contain residual plasma and can have TRALI

Clinical Features

Differential Diagnosis

Transfusion Reaction Types

Diagnosis

  • Time Frame: abrupt to within 6 hours of transfusion initiation

Management

    • Strop transfusion
    • Treat like ARDS
    • Avoid diuresis

Disposition

  • Bilateral pulmonary infiltrates due to noncardiogenic pulmonary edema within 6h of transfusion

See Also

External Links

References