Difference between revisions of "Transfusion-related acute lung injury"

(Differential Diagnosis)
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==Differential Diagnosis==
 
==Differential Diagnosis==
 
{{Transfusion reaction types}}
 
{{Transfusion reaction types}}
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{{Acute Allergic DDX}}
  
 
==Diagnosis==
 
==Diagnosis==

Revision as of 20:59, 4 February 2016

Background

  • Due to granulocyte recruitment and degranulation within the lung
  • More common with FFP and platelet transfusions (extremely rare with pRBC transfusion alone)
    • pRBCs do contain residual plasma and can have TRALI

Clinical Features

Differential Diagnosis

Transfusion Reaction Types

Acute allergic reaction

Diagnosis

  • Time Frame: abrupt to within 6 hours of transfusion initiation

Management

    • Strop transfusion
    • Treat like ARDS
    • Avoid diuresis

Disposition

  • Bilateral pulmonary infiltrates due to noncardiogenic pulmonary edema within 6h of transfusion

See Also

External Links

References