Traveler's diarrhea: Difference between revisions

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==Background==
==Background==
*Most respond to antibiotics
*Most respond to antibiotics
*as duration of diarrhea increases, higher chance of parasitic cause
*As duration of diarrhea increases, higher chance of parasitic cause
*Most cases of traveler’s diarrhea are caused by bacterial enteropathogens, whereas bacterial pathogens cause less than 15% of endemic diarrhea cases in adults living in their home country<ref name="Steffen">Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006</ref>
*At risk populations- Immunosuppressed, diabetes, taking meds to suppress acid production
*Greatest contributor to illness poor hygiene in restaurants <ref> http://wwwnc.cdc.gov/travel/yellowbook/2016/the-pre-travel-consultation/travelers-diarrhea</ref>
 
===Etiology<ref name="Steffen"></ref>===
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Latin America and Caribbean'''
| align="center" style="background:#f0f0f0;"|'''Africa'''
| align="center" style="background:#f0f0f0;"|'''South Asia'''
| align="center" style="background:#f0f0f0;"|'''Southeast Asia'''
|-
| Enterotoxigenic [[Escherichia coli]]|| ≥35|| 25-35 ||15-25|| 5-15
|-
| Enteroaggregative [[E coli]] ||25-35 ||<5 ||15-25 ||No data
|-
| [[Campylobacter]] ||<5 ||<5 ||15-25 ||25-35
|-
| [[Salmonella]]|| <5 ||5-15 ||<5|| 5-15
|-
| [[Shigella]]||5-15 ||5-15|| 5-15 ||<5
|-
| [[Norovirus]] ||15-25||15-25 ||5-15 ||<5
|-
| [[Rotavirus]] ||15-25 ||5-15||5-15 ||<5
|-
| [[Giardia]] ||<5 ||<5 ||5-15 ||5-15
|}
 
==Clinical Features<ref name="Steffen"></ref>==
*Travel
*3 or more unformed stools per 24 hours
*Plus (at least 1 of the following):
**Abdominal cramps
**Tenesmus
**[[Nausea]]
**[[Vomiting]]
**[[Fever]]
**Fecal urgency
 
;The average duration of untreated traveler’s diarrhea is 4 to 5 days


==Differential Diagnosis==
==Differential Diagnosis==
{{Template:Diarrhea DDX}}
{{Template:Diarrhea DDX}}


==Diagnosis==
==Evaluation<ref name="Steffen"></ref>==
# dysentery if stool bloody, fvr or wbc in stool- invasive inflamm enteropathy
===Uncomplicated Diarrhea===
# has abrupt onset, metastatic lesions, reactive arthopathies, or campylobacter assoc guillain barre- maybe flouroquinolone resis esp in SE Asia
*No workup
# amoebic dysentery insidious and can get amoebic liver abscess
 
# if do not find infc cause of dysentery, eval pt for IBD or CA
===Fever, Bloody Stools, or Ill Appearing===
# prolonged diarrhea and malabsorption- giardia or tropical sprue- does not respond to removal of gluten from diet- tx with tetra and folate
*Stool culture
# also consider postinfectious disaccharidase deficiency or irritable bowel dz
*Systemic toxicity
# if diarrhea starts >1 mo after travel- not caused by travel
**Extended workup including blood cultures
 
===Persistent or Refractory Diarrhea (>14 days)===
*Typically not done in the ER (at follow-up)
**Stool culture (including [[Salmonella]], [[Shigella]], and [[Campylobacter]])
**Stool O&P (including testing for protozoal parasites, [[Giardia]], [[Cryptosporidium]])
**Fecal leukocytes, giardia antigen, C. difficile PCR
 
==Management==
*Consider [[ondansteron]] if [[nausea]]
*Consider [[IVF]] if dehydrated
*Consider [[loperamide]] 4mg PO after each loose stool (Max: 16mg/day)<ref name="Steffen"></ref>
**If very frequent stools and no contra-indication:
***Not pregnant
***>2 years old
***[[Fever]] or bloody stools without concomitant antibiotics (do not use as sole therapy)


==Treatment==
===[[Antibiotics]]<ref name="Steffen"></ref>===
===Antibiotics===
{{Travelers Diarrhea Antibiotics}}
{{Travelers Diarrhea Antibiotics}}
===Antimotility agent===
*Only for nonpregnant adults with no fever or blood in stool
*[[Loperamide]] 4mg PO after each loose stool (Max: 16mg/day)


===Pediatrics===
===Pediatrics===
'''Antibiotic Options:'''
'''Antibiotic Options:'''
{{Travelers Diarrhea Pediatric Antibiotics}}
{{Travelers Diarrhea Pediatric Antibiotics}}
==Disposition==
*Outpatient for the vast majority
*Consider admission if systemic toxicity
==Complications==
*[[Postinfectious irritable bowel syndrome]]
*[[Reactive arthritis]]
*[[Guillain-Barre syndrome]]


==See Also==
==See Also==
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*[[Travel Medicine]]
*[[Travel Medicine]]


==Source==
==External Links==
<references/>  
[http://wwwnc.cdc.gov/travel/page/travelers-diarrhea CDC - Travelers Diarrhea]
 
==References==
<references/>  


[[Category:GI]]
[[Category:GI]]
[[Category:ID]]
[[Category:ID]]
[[Category:TropMed]]
[[Category:Tropical Medicine]]

Revision as of 15:05, 14 April 2019

Background

  • Most respond to antibiotics
  • As duration of diarrhea increases, higher chance of parasitic cause
  • Most cases of traveler’s diarrhea are caused by bacterial enteropathogens, whereas bacterial pathogens cause less than 15% of endemic diarrhea cases in adults living in their home country[1]
  • At risk populations- Immunosuppressed, diabetes, taking meds to suppress acid production
  • Greatest contributor to illness poor hygiene in restaurants [2]

Etiology[1]

Organism Latin America and Caribbean Africa South Asia Southeast Asia
Enterotoxigenic Escherichia coli ≥35 25-35 15-25 5-15
Enteroaggregative E coli 25-35 <5 15-25 No data
Campylobacter <5 <5 15-25 25-35
Salmonella <5 5-15 <5 5-15
Shigella 5-15 5-15 5-15 <5
Norovirus 15-25 15-25 5-15 <5
Rotavirus 15-25 5-15 5-15 <5
Giardia <5 <5 5-15 5-15

Clinical Features[1]

  • Travel
  • 3 or more unformed stools per 24 hours
  • Plus (at least 1 of the following):
The average duration of untreated traveler’s diarrhea is 4 to 5 days

Differential Diagnosis

Acute diarrhea

Infectious

Noninfectious

Watery Diarrhea

Traveler's Diarrhea

Evaluation[1]

Uncomplicated Diarrhea

  • No workup

Fever, Bloody Stools, or Ill Appearing

  • Stool culture
  • Systemic toxicity
    • Extended workup including blood cultures

Persistent or Refractory Diarrhea (>14 days)

Management

  • Consider ondansteron if nausea
  • Consider IVF if dehydrated
  • Consider loperamide 4mg PO after each loose stool (Max: 16mg/day)[1]
    • If very frequent stools and no contra-indication:
      • Not pregnant
      • >2 years old
      • Fever or bloody stools without concomitant antibiotics (do not use as sole therapy)

Antibiotics[1]

  • Ciprofloxacin 750mg PO once daily x 1-3 days[4]
    • First choice for use except in South and Southeast Asia[5]
  • Azithromycin 500mg PO q24h x 3 days OR 1000mg PO x 1[6]
    • Nausea is a frequent adverse event[7]
    • First choice for use in South and Southeast Asia[8]
  • Rifaximin 200mg PO TID x 3 days[9]

Pediatrics

Antibiotic Options:

Avoid fluroquinolones

Disposition

  • Outpatient for the vast majority
  • Consider admission if systemic toxicity

Complications

See Also

External Links

CDC - Travelers Diarrhea

References

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  2. http://wwwnc.cdc.gov/travel/yellowbook/2016/the-pre-travel-consultation/travelers-diarrhea
  3. Marx et al. “Cholera and Gastroenteritis caused by Noncholera Vibrio Species”. Rosen’s Emergency Medicine 8th edition vol 1 pg 1245-1246.
  4. Hoge CW. et al. Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis. 1998;26:341–5
  5. Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  6. Sanders JW. et al. An observational clinic-based study of diarrheal illness in deployed United States military personnel in Thailand: presentation and outcome of Campylobacter infection. Am J Trop Med Hyg. 2002;67:533–8
  7. Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  8. Steffen R, et al. Traveler’s Diarrhea: A Clinical Review. JAMA. 2015;313(1):71-80. doi:10.1001/jama.2014.17006
  9. DuPont HL. et al. Rifaximin versus ciprofloxacin for the treatment of traveler’s diarrhea: a randomized, double-blind clinical trial. Clin Infect Dis. 2001;33:1807–15
  10. Stauffer WM, Konop RJ, Kamat D. Traveling with infants and young children. Part III: travelers’ diarrhea. J Travel Med. 2002;9:141–50