Tuberculosis: Difference between revisions

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==Background==
==Background==
[[File:MiliaryTB.png|thumb|Miliary TB neonate born to mother with active TB]]
[[File:MiliaryTB.png|thumb|Miliary TB neonate born to mother with active TB]]
*>1/3 of world's population is infected
*Over 1/3 of world's population is infected[[File:Tuberculosis-x-ray-1.jpg|thumbnail|Bilateral pulmonary tuberculosis]]


===Infection Types===
===Infection Types===
*Primary Infection
*Primary Infection
**Usually contained by body via formation of tubercles
**Usually contained by body via formation of tubercles
**Hematogenous spread limited to areas w/ high O2 or blood flow (apical lung, vertebrae)
**Hematogenous spread limited to areas with high O2 or blood flow (apical lung, vertebrae)
***PPD positive
***PPD positive
*Reactivation Infection
*Reactivation Infection
**More common in immunocompromised pts (AIDS, malignancy, DM, CRF)
**More common in immunocompromised patients (AIDS, malignancy, DM, immunosupressive medications)
*Check HIV in pts suspected of TB
*Miliary Tuberculosis
**Disseminated tuberculosis
**Looks like millet seeds
**Seen in patients with comorbid AIDS
***Check [[HIV]] in patients suspected of TB
**PPD is positive in only 50% of cases


===Special Populations===
===Special Populations===
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***Increased risk when <500
***Increased risk when <500
***Determines the clinical and radiographic presentations of TB
***Determines the clinical and radiographic presentations of TB
*Peds
*Pediatric
**More likely to progress early to active disease
**More likely to progress early to active disease
***Presentation more commonly that of primary TB
***Presentation more commonly that of primary TB
**>5yr - classic symptoms
**>5yr - classic symptoms
**<5yr - miliary TB, meningitis, cervical lymphadenitis, PNA that doesn't respond to abx
**<5yr - milliary TB, meningitis, cervical lymphadenitis, pneumonia that does not respond to usual antibiotics
**Children are usually not infectious due to their weak cough
**Children are usually not infectious due to their weak cough


===Clinical Features===
===Tuberculin Skin Test===
====Primary Tuberculosis====
;Used for population screening, but not for rule-out in patients with concern for active disease
*Usually asymptomatic (only identified by positive PPD)
''Reaction considered positive in following situations:''
*May be rapidly progressive and fatal in immunocompromised pts
*>5 mm
**Fever, malaise, wt loss, chest pain
**[[HIV]] positive
**Close contact with active TB patient
**Nodular or fibrotic changes on CXR
**Immunosuppressed (TNF-alpha inhibitor, chemo, organ transplant)
*>10 mm
**Children < 4 yrs old
**Healthcare/lab/prison employees and residents
**Co-morbid conditions (dialysis, DM, blood/head/neck/lung malignancy, IV drug users)
**People from high prevalence areas
*>15 mm
**Persons with no known risk factors for TB
 
==Clinical Features==
===Primary Tuberculosis===
*Usually asymptomatic (only identified by positive PPD/quantiferon gold)[[File:Screen Shot 2015-09-11 at 9.27.22 AM.png|thumbnail|Tuberculous lymphadenopathy]][[File:Screen Shot 2015-09-11 at 9.21.17 AM.png|thumbnail|Tuberculous vertebral osteomyelitis (Pott's Disease)]]
*May be rapidly progressive and fatal in immunocompromised patients
**Fever, malaise, weight loss, chest pain
*Tuberculous pleural effusion may occur if subpleural node ruptures into the pleura
*Tuberculous pleural effusion may occur if subpleural node ruptures into the pleura
**Pleuritic chest pain
**Pleuritic chest pain
**Exudative fluid
**Exudative fluid
***Organisms may not be visible on acid-fast staining (need pleural biopsy)
***Organisms may not be visible on acid-fast staining (need pleural biopsy)
====Reactivation Tuberculosis====
 
===Reactivation Tuberculosis===
*Pulmonary: Productive cough, hemoptysis, dyspnea, pleuritic chest pain
*Pulmonary: Productive cough, hemoptysis, dyspnea, pleuritic chest pain
*Systemic: Fever, night sweats, malaise, fatigue, wt loss
*Systemic: Fever, night sweats, malaise, fatigue, wt loss
*Extrapulmonary
*Extrapulmonary  
**Lymphadenopathy (painless)
**Painless lymphadenopathy/[[scrofula]] (most common extrapulmonary manifestation)
**Pericarditis
**Pericarditis
**Peritonitis
**Meningitis
**Meningitis
**Adrenal insufficiency
**Adrenal insufficiency
***If adrenals affected, TB typically spreads to bilateral adrenals rather than unilateral
***Think about in the patient presenting in shock with TB risk factors
**Arthritis
**Arthritis
**Osteomyelitis
**Osteomyelitis
***Pott's disease, usually in thoracic spione


==Differential Diagnosis==
==Differential Diagnosis==
{{HIV associated conditions}}
{{HIV associated conditions}}


==Diagnosis==
==Evaluation==
===CXR===
===CXR===
[[File:Miliary.png|thumbnail|CXR of miliary TB]]
*Primary infection
*Primary infection
**Infiltrates in any area of the lung
**Infiltrates in any area of the lung
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**Upper lobe or hilar nodules and fibrotic lesions
**Upper lobe or hilar nodules and fibrotic lesions
**Ghon foci, areas of scarring, calcification
**Ghon foci, areas of scarring, calcification
*HIV pts less likely to have classic lesions and may have normal CXR
*Miliary TB
**Looks like millet seeds on CXR
*Immunocompromised patients less likely to have classic lesions and may have normal CXR
 
===PCR Sputum Assay===
*Rapidly detects TB in sputum specimens (as well as [[rifampin]] resistance)
*Use to rule-out patients for active TB
*Need two sputum specimens (expectorated or induced) at least 8 hours apart (including at least one early morning specimen)


==Treatment==
==Management==
===Active TB===
===Active TB===
*Isoniazid + rifampin + pyrazinamide + ethambutol x8wk followed by INH/RIF x18wk
*[[Isoniazid]] + [[rifampin]] + [[pyrazinamide]] + [[ethambutol]] x 8wk followed by INH/rifampin x18wk
**2 drug continuation tx x 18-31wk
**2 drug continuation treatment x 18-31wk
===Latent TB===
===Latent TB===
*Isoniazid x 9 months
*Consider treatment for:
*Consider treatment for:
**Recent conversion to PPD-positive
**Recent conversion to PPD-positive
**Persons in close contact w/ individual w/ active TB
**close contact with active TB
**Isoniazid x9mo
**immunocompromised patients (or plan to start immunosupressive medications)


==Disposition==
==Disposition==
*Discharge
===Discharge===
**Otherwise healthy
*Otherwise healthy
***Contact public health services before discharge
**Contact public health services before discharge
****Instructions for home isolation and f/u at appropriate clinic to receive meds
***Instructions for home isolation and follow up at appropriate clinic to receive meds
***Do not start TB meds in ED unless specifically instructed by public health
**Do not start TB meds in ED unless specifically instructed by public health
*Admit
 
**Ill-appearing
===Admit===
**Diagnosis is uncertain
*Ill-appearing
**Pt is noncompliant
*Diagnosis is uncertain
*Patient is treatment non-adherent


==References==
<references/>
[[Category:ID]]
[[Category:ID]]
[[Category:Pulm]]
[[Category:Pulmonary]]

Revision as of 19:53, 30 September 2018

Background

Miliary TB neonate born to mother with active TB
  • Over 1/3 of world's population is infected
    Bilateral pulmonary tuberculosis

Infection Types

  • Primary Infection
    • Usually contained by body via formation of tubercles
    • Hematogenous spread limited to areas with high O2 or blood flow (apical lung, vertebrae)
      • PPD positive
  • Reactivation Infection
    • More common in immunocompromised patients (AIDS, malignancy, DM, immunosupressive medications)
  • Miliary Tuberculosis
    • Disseminated tuberculosis
    • Looks like millet seeds
    • Seen in patients with comorbid AIDS
      • Check HIV in patients suspected of TB
    • PPD is positive in only 50% of cases

Special Populations

  • AIDS
    • TB is 200-500x more common in AIDS population than general population
    • CD4 count
      • Increased risk when <500
      • Determines the clinical and radiographic presentations of TB
  • Pediatric
    • More likely to progress early to active disease
      • Presentation more commonly that of primary TB
    • >5yr - classic symptoms
    • <5yr - milliary TB, meningitis, cervical lymphadenitis, pneumonia that does not respond to usual antibiotics
    • Children are usually not infectious due to their weak cough

Tuberculin Skin Test

Used for population screening, but not for rule-out in patients with concern for active disease

Reaction considered positive in following situations:

  • >5 mm
    • HIV positive
    • Close contact with active TB patient
    • Nodular or fibrotic changes on CXR
    • Immunosuppressed (TNF-alpha inhibitor, chemo, organ transplant)
  • >10 mm
    • Children < 4 yrs old
    • Healthcare/lab/prison employees and residents
    • Co-morbid conditions (dialysis, DM, blood/head/neck/lung malignancy, IV drug users)
    • People from high prevalence areas
  • >15 mm
    • Persons with no known risk factors for TB

Clinical Features

Primary Tuberculosis

  • Usually asymptomatic (only identified by positive PPD/quantiferon gold)
    Tuberculous lymphadenopathy
    Tuberculous vertebral osteomyelitis (Pott's Disease)
  • May be rapidly progressive and fatal in immunocompromised patients
    • Fever, malaise, weight loss, chest pain
  • Tuberculous pleural effusion may occur if subpleural node ruptures into the pleura
    • Pleuritic chest pain
    • Exudative fluid
      • Organisms may not be visible on acid-fast staining (need pleural biopsy)

Reactivation Tuberculosis

  • Pulmonary: Productive cough, hemoptysis, dyspnea, pleuritic chest pain
  • Systemic: Fever, night sweats, malaise, fatigue, wt loss
  • Extrapulmonary
    • Painless lymphadenopathy/scrofula (most common extrapulmonary manifestation)
    • Pericarditis
    • Peritonitis
    • Meningitis
    • Adrenal insufficiency
      • If adrenals affected, TB typically spreads to bilateral adrenals rather than unilateral
      • Think about in the patient presenting in shock with TB risk factors
    • Arthritis
    • Osteomyelitis
      • Pott's disease, usually in thoracic spione

Differential Diagnosis

HIV associated conditions

Evaluation

CXR

CXR of miliary TB
  • Primary infection
    • Infiltrates in any area of the lung
    • Isolated hilar or mediastinal adenopathy may be only finding
  • Reactivation infection
    • cavitary/noncavitary lesions in upper lobe or superior segment of lower lobe
  • Latent infection
    • Upper lobe or hilar nodules and fibrotic lesions
    • Ghon foci, areas of scarring, calcification
  • Miliary TB
    • Looks like millet seeds on CXR
  • Immunocompromised patients less likely to have classic lesions and may have normal CXR

PCR Sputum Assay

  • Rapidly detects TB in sputum specimens (as well as rifampin resistance)
  • Use to rule-out patients for active TB
  • Need two sputum specimens (expectorated or induced) at least 8 hours apart (including at least one early morning specimen)

Management

Active TB

Latent TB

  • Isoniazid x 9 months
  • Consider treatment for:
    • Recent conversion to PPD-positive
    • close contact with active TB
    • immunocompromised patients (or plan to start immunosupressive medications)

Disposition

Discharge

  • Otherwise healthy
    • Contact public health services before discharge
      • Instructions for home isolation and follow up at appropriate clinic to receive meds
    • Do not start TB meds in ED unless specifically instructed by public health

Admit

  • Ill-appearing
  • Diagnosis is uncertain
  • Patient is treatment non-adherent

References

  1. Gutteridge, David L MD, MPH, Egan, Daniel J. MD. The HIV-Infected Adult Patient in The Emergency Department: The Changing Landscape of the Disease. Emergency Medicine Practice: An Evidence-Based Approach to Emergency Medicine. Vol 18, Num 2. Feb 2016.