United States Antibiogram

Revision as of 01:22, 24 June 2014 by Rossdonaldson1 (talk | contribs) (Gram Negatives)

Gram Positives[1]

Category Organism Strep. Group A, B, C, G Strep. Pneumoniae Viridans strep Strep. anginosus gp Enterococcus faecalis Enterococcus faecium MSSA MRSA CA-MRSA Staph. Epidermidis C. jeikeium L. monocytogenes
Penicillins Penicillin G S S I S S I R R R R R S
Penicillin V S S I S S I R R R R R R
Anti-Staphylocccal Penicillins Methicillin S S I S R R S R R S R R
Nafcillin/Oxacillin S S I S R R S R R S R R
Cloxacillin/Diclox. S S I S R R S R R S R R
Amino-Penicillins AMP/Amox S S I S S I R R R R R S
Amox-Clav S S I S S S S R R R R X2
AMP-Sulb S S I S S S S R R R R S
Anti-Pseudomonal Penicillins Ticarcillin S S I S I I R R R I R S
Ticar-Clav S S I S I I S R R I R X2
Pip-Tazo S S I S S I S R R S X1 X2
Piperacillin S S I S S I R R R R R S
Carbapenems Doripenem S S S S I R S R R S X1 S
Ertapenem S S S S R R S R R S R I
Imipenem S S S S S I S R R S R S
Meropenem S S S S I R S R R S X1 S
Aztreonam R R R R R R R R R R R R
Fluroquinolones Ciprofloxacin I I R R U R S R I S R S
Ofloxacin I I R R U R S R X1 S R R
Pefloxacin R R X1 X1 R R S R X1 S X1 R
Levofloxacin S S S S S R S R I S X1 S
Moxifloxacin S S S S S I S I I S X1 S
Gemifloxacin S S S S S I S I I S X1 S
Gatifloxacin S S S S S I S I I S X1 S
1st G Cephalo Cefazolin S S S X1 R X1 S R R I R R
2nd G. Cephalo Cefotetan S S S X1 R X1 S R R I R R
Cefoxitin S S S X1 R X1 S R R I R R
Cefuroxime S S S X1 R X1 S R R I R R
3rd/4th G. Cephalo Cefotaxime S S S X1 R X1 S R R I R R
Cefizoxime S S S X1 R X1 S R R I R R
CefTRIAXone S S S X1 R X1 S R R I R R
Ceftaroline S S S X1 S X1 S S S S X1 X1
CefTAZidime S S I X1 R X1 I R R I R R
Cefepime S S S X1 R X1 S R R I X1 R
Oral 1st G. Cephalo Cefadroxil S S S X1 R X1 S R R I R R
Cephalexin S S S X1 R X1 S R R I R R
Oral 2nd G. Cephalo Cefaclor/Loracarbef S S S X1 R X1 S R R I R R
Cefproxil S S R X1 R X1 S R R I R R
Cefuroxime axetil S S S X1 R X1 S R R I R R
Oral 3rd G. Cephalo Cefixime S S S X1 R X1 R R R R R R
Ceftibuten S I R X1 R X1 R R R R R R
Cefpodox/Cefdinir/Cefditoren S S S X1 R X1 S R R I X1 R
Aminoglycosides Gentamicin R R X1 X1 S S S R X1 I R S
Tobramycin R R X1 X1 S R S R X1 I R S
Amikacin R R X1 X1 S R S R X1 I R S
Chloramphenicol S S X1 X1 I I I R X1 R R S
Clindamycin S S X1 X1 R R S R I R R X1
Macrolides Erythromycin I I X1 X1 R R I R I I R S
Azithromycin I I X1 X1 R R S R I R R S
Clarithromycin I I X1 X1 R R S R I R R S
Ketolide Telithromycin S S X1 X1 I R S R I R R S
Tetracyclines Doxycycline I S X1 X1 R R I I S R R S
Minocycline S S X1 X1 R R S I S R R S
Glycylcycline Tigecycline S S X1 X1 S S S S S S S S
Daptomycin S X23 X1 X1 S S S S S S S I
Glyco/Lipoclycopeptides Vancomycin S S X1 X1 S I S S S S S S
Teicoplanin S S X1 X1 S I S S S I S S
Telavancin S S X1 X1 S S S S S S S S
Fusidic Acid I I X1 X1 S X1 S S S S S X1
Trimethoprim S I X1 X1 S R I I S S R S
TMP-SMX X22 S X1 X1 X22 R S S S I R S
Urinary Agents Nitrofurantoin S S X1 X1 S S S S S X1 R X1
Fosfomycin X1 S X1 X1 S I S S S X1 X1 R
Other Rifampin S S X1 X1 I R S S S S S S
Metronidazole R R X1 X1 R R R R R R R R
Quinupristin dalfoppristin S S X1 X1 R S S S S S S S
Linezolid S S X1 X1 S S S S S S S S
Colistimethate R R X1 X1 R R R R R R R R

Gram Negatives

Category Organism N. gonorrhoeae N. meningitidis Moraxella catarrhalis H. influenzae E. coli Klebsiella sp E. coli/Klebsiella ESBL+ E coli/Klebsiella KPC+ Enterobacter sp, AmpC neg Enterobacter sp, AmpC pos Serratia sp Serratia marcescens Salmonella sp Shigella sp Proteus mirabilis Proteus vulgaris Providencia sp. Morganella sp. Citrobacter freundii Citrobacter diversus Citrobacter sp. Aeromonas sp Acinetobacter sp. Pseudomonas aeruginosa Burkholderia cepacia Stenotrophomonas maltophilia Yersinia enterocolitica Francisella tularensis Brucella sp. Legionella sp. Pasteurella multocida Haemophilus ducreyi Vibrio vulnificus
Penicillins Penicillin G R S R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R S S X1
Penicillin V R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R S X1 X1
Anti-Staphylocccal Penicillins Methicillin R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R R X1 X1
Nafcillin/Oxacillin R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R R X1 X1
Cloxacillin/Diclox. R R R R R R R R R R R X1 R R R R R R R R R R R R R R R X1 X1 R R X1 X1
Amino-Penicillins AMP/Amox R S R I I R R R R R R X1 I I S R R R R R R R R R R R R X1 X1 R S R X1
Amox-Clav S S S S S S R R R R R X1 S S S S S I R R R S R R R R I X1 X1 R S S X1
AMP-Sulb S S S S S S R R R R R X1 S S S S S S R R R S S R R R I X1 X1 R S S X1
Anti-Pseudomonal Penicillins Ticarcillin X2 S R I I R R R S S R X1 S S S S S S S S S S R S R X1 I X1 X1 R S X1 X1
Ticar-Clav X2 S S S S S R R S S S X1 S S S S S S S S S S I S X1 S S X1 X1 R S X1 X1
Pip-Tazo X2 S S S S S R R S S S X1 S S S S S S S S S S I S X1 I X1 X1 X1 R X1 X1 X1
Piperacillin X2 S I I S S R R S S S X1 S S S S S S S S S S R S X1 I S X1 X1 R S X1 X1
Carbapenems Doripenem X2 S S S S S S R S S S X1 S S S S S S S S S S I S I R S X1 X1 R S X1 X1
Ertapenem X2 S S S S S S R S S S X1 S S S S S S S S S S R R R R X1 X1 X1 R S X1 X1
Imipenem X2 S S S S S S R S S S X1 S S S S S S S S S S I S R R S X1 X1 R S X1 X1
Meropenem X2 S S S S S S R S S S X1 S S S S S S S S S S I S S R X1 X1 X1 R X1 X1 X1
Aztreonam S S S S S S R R S S S X1 X1 S S S S S S S S S R S R R S X1 X1 R S X1 X1
Fluroquinolones Ciprofloxacin I S S S S S S R S S S X1 S S S S S S S S S S I S R R S X1 X1 S S X1 X1
Ofloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I R R S X1 X1 S S X1 X1
Pefloxacin I S S S S S S R S S S X1 S S S S S S S S S X1 X1 X1 X1 R S X1 X1 S S X1 X1
Levofloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I X1 I S X1 X1 S S X1 X1
Moxifloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I R I S X1 X1 S S X1 X1
Gemifloxacin I X1 S S S S S R S S X1 X1 X1 X1 X1 S X1 X1 X1 X1 X1 X1 I X1 X1 X1 X1 X1 X1 S X1 X1 X1
Gatifloxacin I S S S S S S R S S S X1 S S S S S S S S S S I I R I S X1 X1 S S X1 X1
1st G Cephalo Cefazolin S R I S S S R R R R R X1 X1 X1 S R R R R R R R R R R R R X1 X1 R X1 X1 X1
2nd G. Cephalo Cefotetan I I S S S S R R I R S X1 X1 X1 S S S S R I I S R R R R I X1 X1 R S X1 X1
Cefoxitin I I S S S S R R R R R X1 X1 X1 S S S S R I I I R R R R I X1 X1 R X1 S X1
Cefuroxime I S S S S S R R I R R X1 X1 X1 S S R I R I I S R R R R I X1 X1 R S X1 X1
3rd/4th G. Cephalo Cefotaxime I S S S S S R R S R S X1 S S S S S S S S S S R R I R S X1 X1 R S S X1
Cefizoxime I I S S S S R R S R S X1 S S S S S S R S S S R R I R S X1 X1 R S S X1
CefTRIAXone I S S S S S R R S R S X1 S S S S S S S S S S R R I R S X1 X1 R S S X1
Ceftaroline I S S S S S R R S R S X1 S S S S S S X1 S S S X1 R R R X1 X1 X1 R X1 X1 X1
CefTAZidime I I S S S S R R S R S X1 S S S S S S R S S S I S S I I X1 X1 R X1 S X1
Cefepime I S S S S S R R S R S X1 S S S S S S S S S S I S I R S X1 X1 R S X1 X1
Oral 1st G. Cephalo Cefadroxil R R R X1 S S R R R R R X1 R R S R R R R R X1 X1 R R R R X1 X1 X1 R X1 X1 X1
Cephalexin R R R R S S R R R R R X1 R R S R R R R R R X1 R R R R X1 X1 X1 R R X1 X1
Oral 2nd G. Cephalo Cefaclor/Loracarbef I I I S S S R R R R R X1 X1 X1 S R R R R R I X1 R R R R X1 X1 X1 R X1 X1 X1
Cefproxil I I S S S S R R R R R X1 X1 X1 S R R R R R R X1 R R R R X1 X1 X1 R X1 X1 X1
Cefuroxime axetil I I S S S S R R R R R X1 X1 X1 S R S I R X1 I X1 R R R R X1 X1 X1 R X1 X1 X1
Oral 3rd G. Cephalo Cefixime S I S S S S R R R R I X1 S S S S S R R X1 S S R R R R S X1 X1 R S S X1
Ceftibuten I I S S S S R R I R I X1 S S S S S R R S S S R R S R S X1 X1 R X1 X1 X1
Cefpodox/Cefdinir/Cefditoren S X1 S S S S R R R R R X1 S S S I X1 R R X1 S X1 X1 R X1 X1 X1 X1 X1 R S X1 X1
Aminoglycosides Gentamicin R R S S S S S R S S X1 S X1 S X1 S X1 X1 X1 X1 X1 X1 R S R R S S S+ X1 X1 X1 I
Tobramycin R R S S S S S R S S X1 S X1 S X1 S X1 X1 X1 X1 X1 X1 R S R R S S S+ X1 X1 X1 I
Amikacin R R S S S S S R S S X1 S X1 S X1 S X1 X1 X1 X1 X1 X1 I S R R S S S+ X1 X1 X1 I
Chloramphenicol S S S S S I I R R R X1 R S S X1 I X1 X1 X1 X1 X1 X1 R R S S S S S X1 X1 X2 X2
Clindamycin R R R R R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R X1 X1 X2 X1
Macrolides Erythromycin I X2 I I R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R S X1 S X1
Azithromycin I X2 S S R R R R R R X1 R I I X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R S X1 S X1
Clarithromycin I X1 S S R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R S X1 X1 X1
Ketolide Telithromycin X2 X2 S S R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 R X2 X1 X1 X1
Tetracyclines Doxycycline I S S S S I I R R R X1 R I I X1 R X1 X1 X1 X1 X1 X1 R R R X2 R S S X2 X1 R S+
Minocycline I S S S S I I R R R X1 R I I X1 R X1 X1 X1 X1 X1 X1 S R I R R X1 S X2 X1 R S+
Glycylcycline Tigecycline X2 X1 S S S S S S S S X1 S S S X1 I X1 X1 X1 X1 X1 X1 I R I S X1 X1 X1 X2 X1 X1 X1
Daptomycin R R R R R R R R R R X1 R R X1 X1 R X1 X1 X1 X1 X1 X1 R R R R R R R R X1 R R
Glyco/Lipoclycopeptides Vancomycin R R X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R X1 X1 R X1 X1 R X1
Teicoplanin R R X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R X1 X1 R X1 X1 X1 X1
Telavancin R R X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R X1 X1 R X1 X1 X1 X1
Fusidic Acid S S X1 X1 R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R X1 X1 I X1 X1 R
Trimethoprim R I X1 I S I I R I I X1 R I I X1 R X1 X1 X1 X1 X1 X1 R R S R X1 X1 X2 S X1 R X1
TMP-SMX I X2 S I I I I R X1 X1 X1 I I I X1 R X1 X1 X1 X1 X1 X1 I R S S S S X2 S X1 I X1
Urinary Agents Nitrofurantoin S X1 X1 X1 S I X1 R I I X1 R S S X1 R X1 X1 X1 X1 X1 X1 X1 R R R X1 X1 X1 X1 X1 X1 X1
Fosfomycin X1 X1 X1 X1 S S S S S S X1 S S X1 X1 S X1 X1 X1 X1 X1 X1 R R X1 X1 X1 X1 X1 X1 X1 X1 X1
Other Rifampin X2 S S S R R R I R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R X1 X1 S S+ X1 X1 X1 X1
Metronidazole R R R R R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R R R R X1 R R
Quinupristin dalfoppristin X2 R S I R R R R R R X1 X1 R R X1 X1 X1 X1 X1 X1 X1 X1 X1 R X1 X1 X1 X1 X1 X1 X1 X1 X1
Linezolid X1 R I I R R R R R R X1 R R R X1 R X1 X1 X1 X1 X1 X1 R R R R R R R X1 X1 X1 X1
Colistimethate R R X1 X1 S S S S S S X1 R X1 X1 X1 R X1 X1 X1 X1 X1 X1 S S R I X1 X1 X1 X1 X1 X1 X1

Key

  • S susceptible/sensitive (usually)
  • I intermediate (variably susceptible/resistant)
  • R resistant (or not effective clinically)
  • S+ synergistic with cell wall antibiotics
  • U sensitive for UTI only (non systemic infection)
  • X1 no data
  • X2 active in vitro, but not used clinically
  • X3 active in vitro, but not clinically effective for Group A strep pharyngitis or infections due to E. faecalis
  • X4 active in vitro, but not clinically effective for strep pneumonia

See Also

Source

  1. Sanford Guide to Antimicrobial Therapy 2014