Difference between revisions of "Vancomycin-resistant enterococcus"

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**Use [[streptomycin]] for gentamicin resistance
 
**Use [[streptomycin]] for gentamicin resistance
 
**Add [[ampicillin]] 12 g q24hrs IV if treating [[endocarditis]] or [[vancomycin]] if suspicious for MRSA
 
**Add [[ampicillin]] 12 g q24hrs IV if treating [[endocarditis]] or [[vancomycin]] if suspicious for MRSA
*[[Linezolid]] 600 mg PO/IV q12hrs
+
*[[Linezolid]] 600 mg PO/IV q12hrs, with exception of bacteremia since agent is bacteriostatic
 
*[[Daptomycin]] 6 mg/kg q24hrs  
 
*[[Daptomycin]] 6 mg/kg q24hrs  
 
**Cannot be used for pulmonary infection
 
**Cannot be used for pulmonary infection

Revision as of 23:25, 28 August 2016

Background

Antimicrobial Options[1][2]

  • Gentamicin 1 mg/kg q8hrs IV
  • Linezolid 600 mg PO/IV q12hrs, with exception of bacteremia since agent is bacteriostatic
  • Daptomycin 6 mg/kg q24hrs
    • Cannot be used for pulmonary infection
    • Daptomycin is inactivated by surfactant by in vitro studies

See Also

Sources

  1. Arias CA et al. Management of multidrug-resistant enterococcal infections. Clin Microbiol Infect. 2010 Jun; 16(6): 10.1111/j.1469-0691.
  2. Rivera AM and Boucher HW. Current Concepts in Antimicrobial Therapy Against Select Gram-Positive Organisms: Methicillin-Resistant Staphylococcus aureus, Penicillin-Resistant Pneumococci, and Vancomycin-Resistant Enterococci. Mayo Clin Proc. 2011 Dec; 86(12): 1230–1243.