Amphotericin B

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  • Type: Antifungal
  • Dosage Forms: powder for injection
  • Dosage Strengths: 50mg/vial
  • Routes of Administration: IV
  • Common Trade Names: AmBisome, Fungizone "ampho-terrible"

Adult Dosing

Dosing is NOT interchangeable between different formulations of amphotericin B due to significant variations in pharmacokinetics. Call your institution's pharmacy (or ID) if unsure about correct dose.

Pediatric Dosing

Special Populations

Renal Dosing

  • Adult:
  • Pediatric:

Hepatic Dosing

  • Adult:
  • Pediatric:


  • Allergy to class/drug

Adverse Reactions


  • Nephrotoxicity/renal failure, hemorrhagic cystitis
  • Anaphylaxis
  • Cardiac arrest


  • Hypokalemia, hypomagnesemia, hyperglycemia (check BMP at least daily)
  • Rigors
  • Nausea/vomiting, diarrhea
  • Anemia
  • Rash
  • Dyspnea
  • Insomnia


  • Half-life: Depends on formulation, 1-14 days
  • Metabolism: unknown
  • Excretion: urine

Mechanism of Action

  • Binds to ergosterol in fungal cell membranes→ intracellular contents leak out→ cell dies


Amphotericin B is an antifungal agent used to treat severe or disseminated fungal infections (e.g. invasive aspergillosis, cryptoccoccal meningitis, coccidioidomycosis, mucormycosis, fungemia in neutropenic patients). It comes in several formulations; conventional, cholesteryl sulfate complex, lipid complex, and liposomal. It is usually reserved for serious infection due to significant associated toxicities, though the newer formulations tend to be better tolerated.

See Also