Anticoagulants

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==Contraindications to Anticoagulation[1]

  • Absolute:
    • Active bleeding
    • Severe bleeding diathesis or platelet count <20K
    • Neurosurgery, ocular surgery, or intracranial bleeding in the last 10 days
  • Relative:
    • Mild-to-moderate bleeding diathesis or thrombocytopenia
    • Brain metastases
    • Recent major trauma
    • Major abdominal surgery within the past 2 days
    • GI or GU bleeding within the past 14 days
    • Endocarditis
    • Severe hypertension (>200/120mmHg) at presentation

Vitamin K Antagonist

Blocks activation of vitamin K dependent prothrombotic factors II, VII, IX, X and blocks synthesis of vitamin K dependent ANTI-thrombotic proteins C and S

Heparins

Bind to and activate antithrombin, which in turns inactivates factor Xa and thrombin

Factor Xa Inhibitors

Inhibits Factor Xa, leading to inactivation of thrombin

Direct Thrombin Inhibitors

Self-explanatory

See Also

  • Bates SM, Ginsberg JS. Treatment of deep-vein thrombosis. N Engl J Med. 2004;351(3):268–277.