(Redirected from Anticoagulation)

Contraindications to Anticoagulation[1]

  • Absolute:
    • Active bleeding
    • Severe bleeding diathesis or platelet count <20K
    • Neurosurgery, ocular surgery, or intracranial bleeding in the last 10 days
  • Relative:
    • Mild-to-moderate bleeding diathesis or thrombocytopenia
    • Brain metastases
    • Recent major trauma
    • Major abdominal surgery within the past 2 days
    • GI or GU bleeding within the past 14 days
    • Endocarditis
    • Severe hypertension (>200/120mmHg) at presentation

Vitamin K Antagonist

Blocks activation of vitamin K dependent prothrombotic factors II, VII, IX, X and blocks synthesis of vitamin K dependent ANTI-thrombotic proteins C and S


Bind to and activate antithrombin, which in turns inactivates factor Xa and thrombin

Parenteral Factor Xa Inhibitors

Direct oral anticoagulants (DOACs)

Factor Xa Inhibitors

Inhibits Factor Xa, leading to inactivation of thrombin

Direct Thrombin Inhibitors

Directly inhibits thrombin

See Also


  1. Bates SM, Ginsberg JS. Treatment of deep-vein thrombosis. N Engl J Med. 2004;351(3):268–277.