CMV esophagitis


  • Cytomegalovirus (CMV) gastrointestinal disease is an uncommon but serious complication of AIDS.
  • The diagnosis of CMV gastrointestinal disease should be suspected in patients with CD4 cell counts <50 cells/microL who present with symptoms of esophagitis, gastritis, enteritis, or colitis.
  • The incidence of CMV gastrointestinal disease has decreased substantially since antiretroviral therapy (ART) became available

Clinical Features

Differential Diagnosis

Esophagitis Types

CMV Diseases



    • Ganciclovir: 5mg/kg/dose IV q12h
    • Foscarnet: 60mg/kg/dose q8h or 90mg/kg/dose q12h
    • Valganciclovir: 900mg PO twice daily
      • May be used for induction therapy, in place of intravenous ganciclovir, in patients who can tolerate and absorb oral medications
    • The recommended duration of therapy for CMV gastrointestinal disease in patients with AIDS is 3-6 weeks
    • Chronic maintenance therapy is not recommended for CMV gastrointestinal disease unless there is concurrent retinitis or recurrent gastrointestinal disease after induction therapy has been discontinued.


See Also

External Links