Cocaine

This page is for the drug cocaine; for clinical effects see cocaine toxicity

Administration

• Type: Local anesthetic
• Dosage Forms: 4% solution; 10% solution
• Routes of Administration: Topical
• Common Trade Names: Cocaine

Adult Dosing

• 1-3 mg/kg, max dose of 200 mg
  • Some literature suggests maximum dose of 100 mg
  • Ideally use lowest effective dose

Pediatric Dosing

• 1 mg/kg
  • No clear safe dose established

Special Populations

• Pregnancy Rating: Category C
• Lactation risk: Infant risk has been demonstrated

Renal Dosing

• Adult: N/A
• Pediatric: N/A

Hepatic Dosing

• Adult: N/A
• Pediatric: N/A

Contraindications

• Allergy to class/drug

Adverse Reactions

• Cocaine-associated chest pain
• Sympathomimetic qualities
  • Tachycardia
  • Fever
  • Agitation
  • Diaphoresis

Pharmacology

• Half-life: 50 to 75 minutes (5.5 hours benzoylecgonine metabolite)
• Metabolism: Plasma cholinesterase; liver
• Excretion: Renal

Mechanism of Action

• Blocks reuptake of serotonin, dopamine and norepinephrine
• Anesthetic effects achieved through sodium channel blockade

See Also

• Cocaine toxicity

References

Micromedex