Erythema nodosum


  • Often marker for systemic disease
  • Most common in women 30-50 years of age
    • 1:6 male to female
  • Usually a self-limited disease, resolving in 3-6 wks

Associated Disease Processes

Clinical Features

Erythema nodosum in a person who had recently had streptococcal pharyngitis
A single lesion of erythema nodosum.
Erythema nodosum.JPG
  • Painful
  • Non-ulcerative nodules
  • Violaceous, erythematous
  • Usually anterior tibia, arms, trunk

Differential Diagnosis


Erythema nodosum. (A) Symmetric, smooth and shiny, erythematous nodules affecting the both shins of the parient. (B) Classical appearance of septal inflammation.
  • Clinical diagnosis


  • Treat underlying cause
  • NSAIDs
  • Potassium Iodide
  • RICE, cool wet compresses


  • Typically outpatient


  1. Schwartz, R., Nervi, S. Am Fam Physician. 2007 Mar 1;75(5):695-700.