Famiciclovir

Administration

  • Type: Antiviral
  • Dosage Forms:
  • Routes of Administration: Oral
  • Common Trade Names: Famvir

Adult Dosing

  • 150-1000mg PO BID

Pediatric Dosing

Safety/efficacy not established

Special Populations

  • Pregnancy Rating: B
  • Lactation risk: Infant risk cannot be ruled out
  • Renal dosing: reduced dose
  • Hepatic dosing: no adjustment for mild-moderate impairment

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Neutropenia
  • Elevated AST/ALT

Common

  • Nausea/vomiting, diarrhea
  • Headache
  • Fatigue

Pharmacology

  • Half-life: 2.3h
  • Metabolism: Hepatic
  • Excretion: Mostly renal

Mechanism of Action

  • Inhibits viral DNA synthesis

Comments

See Also

References

Authors:

Claire