Marfan syndrome

(Redirected from Marfan's syndrome)

Background

  • Hereditary connective tissue disorder
    • Caused by autosomal-dominant mutation in fibrillin gene (FBN1)
    • 75% of cases are autosomal dominant with different features among family members
    • 25% mutations occur spontaneously, though may be associated with older paternal age

Clinical Features

Increased risk of: