Purpura fulminans

(Redirected from Purpural fulminans)


  • Life-threatening syndrome of intravascular coagulation and hemmorrhagic skin infarction→ DIC and vascular collapse
  • Usually occurs in children, but can occur in adults
  • Most commonly in the setting of overwhelming sepsis OR 7-10 days after infection


Clinical Features

Neonatal purpura fulminans
Purpura fulminans

Differential Diagnosis

Petechiae/Purpura (by findings)


  • DIC work up
    • CBC, PT/PTT, fibrinogen, d-dimer, FDP
  • Infectious work up


  • Treat shock
  • Treat underlying infection
  • Necrotic tissue may require debridement
  • Coagulopathy correction, in some cases
    • Typically only if bleeding or need for procedure
      • Exception: FFP usually indicated for neonatal purpura fulminans
    • Cryoprecipitate: consider if fibrinogen <100
    • Platelets: consider repletion if <50K with bleeding or <20K without bleeding
    • FFP: consider repletion to goal of PT and PTT < 1.5 times the normal limit
    • Vitamin K, folate


  • Admit!

See Also

External Links