Remdesivir

Administration

  • Type: Antiviral
  • Dosage Forms: 100 mg, 200 mg
  • Routes of Administration: IV
  • Common Trade Names: N/a

Adult Dosing

  • Loading dose: 200 mg IV administered on day 1
  • Maintenance dose: 100 mg IV daily for duration of hospitalization, up to 10 days[1]

Pediatric Dosing

  • Not studied in pediatric patients

Special Populations

Pregnancy Rating

  • No data

Lactation risk

  • No data

Renal Dosing

  • Adult: Unknown
  • Pediatric: Unknown

Hepatic Dosing

  • Adult: Unknown
  • Pediatric: Unknown

Contraindications

  • Allergy to class/drug

Adverse Reactions

Serious

  • Unknown

Common

  • Unknown

Pharmacology

  • Half-life: Unknown
  • Metabolism: Unknown
  • Excretion: Unknown

Mechanism of Action

  • Adenosine nucleotide analog that interferes with the action of viral RNA polymerase, resulting in decreased virus production[2]

Comments

Remdesivir is a novel antiviral currently being studied in clinical trials for use in COVID-19. It was initially developed for treatment of Ebola and has also been shown to have some effect on SARS and MERS, as well as some other RNA viruses.[3]

See Also

References

  1. Gilead Sciences. Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734™) in Participants With Severe Coronavirus Disease (COVID-19). Available from: https://clinicaltrials.gov/ct2/show/NCT04292899. NLM identifier: NCT04292899. Accessed March 21, 2020.
  2. US 9724360, Chun BK, Clarke MO, Doerffler E, Hui HC, Jordan R, Mackman RL, Parrish JP, Ray AS, Siegel D, "Methods for treating Filoviridae virus infections", issued 19 July 2017, assigned to Gilead Sciences Inc.
  3. Warren TK, Jordan R, Lo MK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys [published correction appears in ACS Chem Biol. 2016 May 20;11(5):1463]. Nature. 2016;531(7594):381–385. doi:10.1038/nature17180