- Abnormal collection of inflammatory cells (granulomas) throughout the body.
- Most common location for granulomas to occur are the lung, skin, heart, and brain.
- Exact cause unknown - thought to be related to an immune reaction to a prior insult such as infection or chemical exposure earlier in life.
- Do not confuse with infectious granulomatous processes such as tuberculosis.
Depend on location of granulomata. May be entirely asymptomatic.
- Erythema nodosum and other skin lesions
- Weight loss
- Restrictive cardiomyopathy
- Arrythmias due to conduction disturbance
- Dacryoadenitis (lacrimal duct inflammation)
- Optic neuritis
- Histiocytosis X
- Wegener's granulomatosis
- Churg-Strauss syndrome
- Rheumatoid arthritis
- Polymyalgia rheumatica