Template:Epiglottitis Antibiotics

Coverage targets Streptococcus pneumoniae, Staphylococcus pyogenes, and Haemophilus influenzae, and H. parainfluenzae

Immunocompetent

• Ceftriaxone 2gm IV once daily (first line) OR
• Cefotaxime 2gm (50mg/kg) IV three times daily OR
• Ampicillin/Sulbactam 3g (50mg/kg) IV q 6 hours OR
• Levofloxacin 750mg IV once daily
• Consider Vancomycin 15-20mg/kg IV to any of the above if risk of MRSA

Immunocompromised

Coverage should extend to all of the typical organisms above as well as Pseudomonas, M. tuberculosis, and C. albicans

• Cefepime 2g (50/kg) IV q8 hours AND Vancomycin 15mg/kg IV q6 hours

Young LS, Price CS. Complicated adult epiglottitis due to methicillin-resistant Staphylococcus aureus. Am J Otolaryngol. Nov-Dec 2007;28(6):441-3.