Toxic megacolon

Background

  • Colonic Dilation ≥6cm
  • Therapy: Fluids, Electrolyte Repletion, Steroids, Antibiotics, Surgical Consultation
  • AVOID anticholingerics, anti-motility agents, opioids

Causes

Clinical Features

Differential Diagnosis

Evaluation

Toxic megacolon on KUB

Management

  • Obtain blood cultures, stool cultures, C. Diff Toxin
  • If known cause is C. Diff treat with Vancomycin or Metronidazole
  • If known cause is CMV can add Ganciclovir
  • Avoid
    • Anticholinergics, anti-motility agents, opioids which can worsen dilation
    • Sulfasalazine or 5-aminosalicylate (5-ASA) unhelpful
    • Nasogastric (NG) Tube NOT effective in reducing colonic distention

Disposition

  • Admit

See Also

References