(Redirected from Troponins)


  • During contraction of muscle, thick filaments of myosin slide past thin filaments of actin by calcium-mediated ATP-dependent contraction
    • Released calcium binds to troponin C, T, and I, which regulate muscle contraction
  • Troponins do not change in trauma, skeletal muscle disease, exercise
  • Troponin C found in all tissue and is not cardiac marker
  • Troponin T is qualitative assay
  • Troponin I is quantitative assay
  • High sensitivity troponin T (hsTnT) is a quantitative assay

Cardiac Enzymes Over Time

Type Interval (hours) Peak Elevation (hours) Return to Normal
Myoglobin 1-4 6-7 18-24 hours
Troponin I 3-12 10-24 3-10 days
Troponin T 3-12 10-24 5-14 days
CK-MB 4-12 12-24 2-3 days
LDH 8-12 24-48 10-14 days

Differential Diagnosis

Elevated Troponin

True Positive

False (Non-CAD) Positives

See Also

External Links


  • Jain N, Hedayati SS. How should clinicians interpret cardiac troponin values in patients with ESRD? Seminars in dialysis. 2011;24(4):398-400. doi:10.1111/j.1525-139X.2011.00912.x.
  • Ellis K, Dreisbach AW, Lertora JL. Plasma elimination of cardiac troponin I in end-stage renal disease. South Med J. 2001 Oct;94(10):993-6. PubMed PMID: 11702827.