View source for Pyrimethamine

''Note: As of 2015, pyrimethamine is only available in the US through a special pharmacy program''<ref>https://aidsinfo.nih.gov/news/1604/notice-of-availability-of-pyrimethamine</ref>
==Administration==
*Type: [[Antiparasitic]], indicated for treatment and prophylaxis of [[Toxoplasmosis]] and [[malaria]]
*Dosage Forms: 
*Routes of Administration: Oral
*Common Trade Names:

==Adult Dosing==
*25-200mg PO (weekly or daily, depending on indication), in combination with other antimicrobials

==Pediatric Dosing==
*1-3mg/kg PO

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk minimal
*Renal dosing: 

==Contraindications==
*Allergy to class/drug
*megaloblastic anemia due to folate deficiency

==Adverse Reactions==
===Serious===
*SJS, TEN
*Pancytopenia, leukopenia, thrombocytopenia, megaloblastic anemia
===Common===
*Rash
==Pharmacology==
*Half-life: 52-97 hours 
*Metabolism: Hepatic
*Excretion: 

==Mechanism of Action==
*Blocks protozoal dihydrofolate reductase, inhibiting nucleic acid synthesis
==Comments==

==See Also==

==References==
<references/>
[[Category:Pharmacology]]
[[Category:ID]]