SIADH: Difference between revisions
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*Absence of adrenal, thyroid, pituitary or renal insufficiency | *Absence of adrenal, thyroid, pituitary or renal insufficiency | ||
*No recent use of diuretic agents | *No recent use of diuretic agents | ||
==Supplemental criteria== | ===Supplemental criteria=== | ||
*Serum uric acid <0.24 mmol/l (<4 mg/dl) | *Serum uric acid <0.24 mmol/l (<4 mg/dl) | ||
*Serum urea <3.6 mmol/l (<21.6 mg/dl) | *Serum urea <3.6 mmol/l (<21.6 mg/dl) | ||
Revision as of 00:40, 23 April 2015
Diagnosis
Essential Criteria[1]
- Effective serum osmolality <275 mOsm/kg
- Urine osmolality >100 mOsm/kg at some level of decreased effective osmolality
- Clinical euvolaemia
- Urine sodium concentration >30 mmol/l with normal dietary salt and water intake
- Absence of adrenal, thyroid, pituitary or renal insufficiency
- No recent use of diuretic agents
Supplemental criteria
- Serum uric acid <0.24 mmol/l (<4 mg/dl)
- Serum urea <3.6 mmol/l (<21.6 mg/dl)
- Failure to correct hyponatraemia after 0.9% saline infusion
- Fractional sodium excretion >0.5%
- Fractional urea excretion >55%
- Fractional uric acid excretion >12%
- Correction of hyponatraemia through fluid restriction
References
- ↑ Schwartz WB, Bennett W, Curelop S, Bartter FC. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. American Journal of Medicine 1957 23 529–542